FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912496853> ?p ?o ?g. }

• W2912496853 endingPage "727" @default.
• W2912496853 startingPage "719" @default.
• W2912496853 abstract "T helper (Th)2 polarization plays an important role in the pathogenesis of allergic diseases; the underlying mechanism remains to be further investigated. B cell lymphoma protein-2 like protein-12 (Bcl2L12) has the anti-apoptotic function. This study aims to elucidate the contribution of Bcl2L12 to Th2 polarization in patients with allergic rhinitis (AR). In this study, human CD4+ T cells were isolated from blood samples collected from AR patients and healthy control (HC) subjects. The immune response profiles of CD4+ T cells were analyzed by immunologic approaches. The results showed that AR CD4+ T cells (CD4+ T cells collected from AR patients) showed defects of apoptosis. The expression of FasL in AR CD4+ T cells was lower than that of HC CD4+ T cells. Serum IL-5 levels were negatively correlated with the expression of FasL in AR CD4+ T cells. Exposure of CD4+ T cells to IL-5 in the culture suppressed the expression of FasL and increased the expression of Bcl2L12. IL-5 increased the levels of Bcl2L12 in CD4+ T cells, the latter bound to the FasL promoter to prevent FasL gene transcription. Inhibition of Bcl2L12 restored the apoptosis machinery in AR CD4+ T cells. In conclusion, overexpression of Bcl2L12 in CD4+ T cells compromises the apoptosis machinery; the latter can be restored by inhibition of Bcl2L12. BcL2L12 in CD4+ T cells may be a novel target for the treatment of AR and other allergic disorders." @default.
• W2912496853 created "2019-02-21" @default.
• W2912496853 creator A5005117527 @default.
• W2912496853 creator A5006901857 @default.
• W2912496853 creator A5009638692 @default.
• W2912496853 creator A5014810570 @default.
• W2912496853 creator A5015601864 @default.
• W2912496853 creator A5027850873 @default.
• W2912496853 creator A5038666080 @default.
• W2912496853 creator A5048704192 @default.
• W2912496853 creator A5053220969 @default.
• W2912496853 creator A5056037630 @default.
• W2912496853 creator A5058569786 @default.
• W2912496853 creator A5076395831 @default.
• W2912496853 date "2019-01-29" @default.
• W2912496853 modified "2023-10-16" @default.
• W2912496853 title "Interleukin-5 induces apoptotic defects in CD4+ T cells of patients with allergic rhinitis" @default.
• W2912496853 cites W1520154627 @default.
• W2912496853 cites W1897271284 @default.
• W2912496853 cites W1911339339 @default.
• W2912496853 cites W1929605979 @default.
• W2912496853 cites W1988333687 @default.
• W2912496853 cites W2009194913 @default.
• W2912496853 cites W2031344762 @default.
• W2912496853 cites W2050409153 @default.
• W2912496853 cites W2056743382 @default.
• W2912496853 cites W2080002001 @default.
• W2912496853 cites W2087165333 @default.
• W2912496853 cites W2146828787 @default.
• W2912496853 cites W2321135911 @default.
• W2912496853 cites W2330979714 @default.
• W2912496853 cites W2581093410 @default.
• W2912496853 cites W2605749793 @default.
• W2912496853 cites W2806387963 @default.
• W2912496853 cites W4244060892 @default.
• W2912496853 doi "https://doi.org/10.1002/jlb.3a0718-287rr" @default.
• W2912496853 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30694585" @default.
• W2912496853 hasPublicationYear "2019" @default.
• W2912496853 type Work @default.
• W2912496853 sameAs 2912496853 @default.
• W2912496853 citedByCount "10" @default.
• W2912496853 countsByYear W29124968532020 @default.
• W2912496853 countsByYear W29124968532021 @default.
• W2912496853 countsByYear W29124968532022 @default.
• W2912496853 countsByYear W29124968532023 @default.
• W2912496853 crossrefType "journal-article" @default.
• W2912496853 hasAuthorship W2912496853A5005117527 @default.
• W2912496853 hasAuthorship W2912496853A5006901857 @default.
• W2912496853 hasAuthorship W2912496853A5009638692 @default.
• W2912496853 hasAuthorship W2912496853A5014810570 @default.
• W2912496853 hasAuthorship W2912496853A5015601864 @default.
• W2912496853 hasAuthorship W2912496853A5027850873 @default.
• W2912496853 hasAuthorship W2912496853A5038666080 @default.
• W2912496853 hasAuthorship W2912496853A5048704192 @default.
• W2912496853 hasAuthorship W2912496853A5053220969 @default.
• W2912496853 hasAuthorship W2912496853A5056037630 @default.
• W2912496853 hasAuthorship W2912496853A5058569786 @default.
• W2912496853 hasAuthorship W2912496853A5076395831 @default.
• W2912496853 hasBestOaLocation W29124968531 @default.
• W2912496853 hasConcept C129374314 @default.
• W2912496853 hasConcept C153911025 @default.
• W2912496853 hasConcept C179464577 @default.
• W2912496853 hasConcept C190283241 @default.
• W2912496853 hasConcept C203014093 @default.
• W2912496853 hasConcept C2776090121 @default.
• W2912496853 hasConcept C2780942790 @default.
• W2912496853 hasConcept C31573885 @default.
• W2912496853 hasConcept C502942594 @default.
• W2912496853 hasConcept C55493867 @default.
• W2912496853 hasConcept C66008609 @default.
• W2912496853 hasConcept C86803240 @default.
• W2912496853 hasConcept C8891405 @default.
• W2912496853 hasConceptScore W2912496853C129374314 @default.
• W2912496853 hasConceptScore W2912496853C153911025 @default.
• W2912496853 hasConceptScore W2912496853C179464577 @default.
• W2912496853 hasConceptScore W2912496853C190283241 @default.
• W2912496853 hasConceptScore W2912496853C203014093 @default.
• W2912496853 hasConceptScore W2912496853C2776090121 @default.
• W2912496853 hasConceptScore W2912496853C2780942790 @default.
• W2912496853 hasConceptScore W2912496853C31573885 @default.
• W2912496853 hasConceptScore W2912496853C502942594 @default.
• W2912496853 hasConceptScore W2912496853C55493867 @default.
• W2912496853 hasConceptScore W2912496853C66008609 @default.
• W2912496853 hasConceptScore W2912496853C86803240 @default.
• W2912496853 hasConceptScore W2912496853C8891405 @default.
• W2912496853 hasFunder F4320321001 @default.
• W2912496853 hasFunder F4320321921 @default.
• W2912496853 hasIssue "4" @default.
• W2912496853 hasLocation W29124968531 @default.
• W2912496853 hasLocation W29124968532 @default.
• W2912496853 hasOpenAccess W2912496853 @default.
• W2912496853 hasPrimaryLocation W29124968531 @default.
• W2912496853 hasRelatedWork W1993667514 @default.
• W2912496853 hasRelatedWork W2044819547 @default.
• W2912496853 hasRelatedWork W2072381168 @default.
• W2912496853 hasRelatedWork W2078438248 @default.
• W2912496853 hasRelatedWork W2081053791 @default.
• W2912496853 hasRelatedWork W2358450154 @default.

• next