Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912500870> ?p ?o ?g. }
- W2912500870 endingPage "247" @default.
- W2912500870 startingPage "237" @default.
- W2912500870 abstract "Elevated serum low-density lipoprotein cholesterol (LDL-C) is a major risk factor for coronary heart disease (CHD). Many guidelines recommend LDL-C as a primary treatment target, and statins represent the cornerstone of treatment for lipid management. Recently revised guidelines recommend even more intense management of LDL-C, especially in patients at moderate and high risk. However, LDL-C levels in the Chinese population differ from those in Western populations, and the benefits and safety of the maximum allowable dose of statins have yet to be determined. Furthermore, in practice, many patients do not achieve the increasingly stringent LDL-C goals. Consequently, alternative approaches to lipid management are required. Combination therapy with ezetimibe and a statin, which have complementary mechanisms of action, is more effective than statin monotherapies, even at high doses. Several clinical studies have consistently shown that combination therapy with ezetimibe and simvastatin lowers LDL-C more potently than statin monotherapies. Moreover, the safety and tolerability profile of the combination therapy appears to be similar to that of low-dose statin monotherapies. This review discusses the role of simvastatin in combination with ezetimibe in controlling dyslipidemia in Chinese patients, particularly the efficacy and safety of combination therapy in light of recently published clinical data." @default.
- W2912500870 created "2019-02-21" @default.
- W2912500870 creator A5007589554 @default.
- W2912500870 creator A5040866457 @default.
- W2912500870 creator A5041967407 @default.
- W2912500870 creator A5059856256 @default.
- W2912500870 creator A5062026165 @default.
- W2912500870 date "2019-02-04" @default.
- W2912500870 modified "2023-10-08" @default.
- W2912500870 title "Drug Treatment of Hyperlipidemia in Chinese Patients: Focus on the Use of Simvastatin and Ezetimibe Alone and in Combination" @default.
- W2912500870 cites W1498903994 @default.
- W2912500870 cites W1520609538 @default.
- W2912500870 cites W1548555206 @default.
- W2912500870 cites W1606937999 @default.
- W2912500870 cites W1799873623 @default.
- W2912500870 cites W1929833741 @default.
- W2912500870 cites W1971854626 @default.
- W2912500870 cites W1990063973 @default.
- W2912500870 cites W1990873768 @default.
- W2912500870 cites W1992084132 @default.
- W2912500870 cites W1992562748 @default.
- W2912500870 cites W1994224504 @default.
- W2912500870 cites W1995196487 @default.
- W2912500870 cites W1995419786 @default.
- W2912500870 cites W1998336053 @default.
- W2912500870 cites W2002487447 @default.
- W2912500870 cites W2004668949 @default.
- W2912500870 cites W2006572302 @default.
- W2912500870 cites W2008262437 @default.
- W2912500870 cites W2010033213 @default.
- W2912500870 cites W2018126221 @default.
- W2912500870 cites W2020171842 @default.
- W2912500870 cites W2025800563 @default.
- W2912500870 cites W2029158612 @default.
- W2912500870 cites W2032890774 @default.
- W2912500870 cites W2033048555 @default.
- W2912500870 cites W2034336678 @default.
- W2912500870 cites W2040377539 @default.
- W2912500870 cites W2040811141 @default.
- W2912500870 cites W2042873619 @default.
- W2912500870 cites W2043425870 @default.
- W2912500870 cites W2043777332 @default.
- W2912500870 cites W2046057128 @default.
- W2912500870 cites W2052094004 @default.
- W2912500870 cites W2052316247 @default.
- W2912500870 cites W2057332293 @default.
- W2912500870 cites W2059078444 @default.
- W2912500870 cites W2060143627 @default.
- W2912500870 cites W2071155446 @default.
- W2912500870 cites W2079874135 @default.
- W2912500870 cites W2082559134 @default.
- W2912500870 cites W2085832511 @default.
- W2912500870 cites W2087442315 @default.
- W2912500870 cites W2089128978 @default.
- W2912500870 cites W2093739200 @default.
- W2912500870 cites W2094929865 @default.
- W2912500870 cites W2103239857 @default.
- W2912500870 cites W2104982711 @default.
- W2912500870 cites W2105641097 @default.
- W2912500870 cites W2111385165 @default.
- W2912500870 cites W2116108398 @default.
- W2912500870 cites W2116646125 @default.
- W2912500870 cites W2117592927 @default.
- W2912500870 cites W2121116134 @default.
- W2912500870 cites W2123936150 @default.
- W2912500870 cites W2133247967 @default.
- W2912500870 cites W2134068835 @default.
- W2912500870 cites W2135154055 @default.
- W2912500870 cites W2136859326 @default.
- W2912500870 cites W2141676927 @default.
- W2912500870 cites W2150499586 @default.
- W2912500870 cites W2160609898 @default.
- W2912500870 cites W2163252871 @default.
- W2912500870 cites W2163455636 @default.
- W2912500870 cites W2165624352 @default.
- W2912500870 cites W2168650051 @default.
- W2912500870 cites W2170525407 @default.
- W2912500870 cites W2200285648 @default.
- W2912500870 cites W2211642628 @default.
- W2912500870 cites W2213024535 @default.
- W2912500870 cites W2292665934 @default.
- W2912500870 cites W2330765162 @default.
- W2912500870 cites W2332339883 @default.
- W2912500870 cites W2346605726 @default.
- W2912500870 cites W2410405995 @default.
- W2912500870 cites W2410785151 @default.
- W2912500870 cites W2418946833 @default.
- W2912500870 cites W2463656144 @default.
- W2912500870 cites W2463742437 @default.
- W2912500870 cites W2465758073 @default.
- W2912500870 cites W2496801530 @default.
- W2912500870 cites W2509676484 @default.
- W2912500870 cites W2519634482 @default.
- W2912500870 cites W2520219176 @default.
- W2912500870 cites W2617792817 @default.
- W2912500870 cites W2899895024 @default.
- W2912500870 cites W3021842026 @default.
- W2912500870 cites W4230870013 @default.