FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912505315> ?p ?o ?g. }

• W2912505315 endingPage "905" @default.
• W2912505315 startingPage "893" @default.
• W2912505315 abstract "Abstract Background Fumaric acid esters ( FAE s) are used to treat psoriasis and are known to cause lymphopenia in roughly 60% of the patients. Much remains to be elucidated about the biological effects of FAE s on lymphocytes. Objective To evaluate the influence of long‐term FAE (Fumaderm ® ) treatment on peripheral blood CD 4 + and CD 8 + T cells, CD 19 + B cells and CD 56 + natural killer ( NK ) cells in psoriasis. Methods In this single‐centre retrospective observational subcohort study, we obtained leucocyte and lymphocyte subset counts before initiating FAE therapy in 371 psoriasis patients (mean age, 47.8 years; 63.3% males) and monitored them during treatment (mean treatment duration, 2.9 years). Multiparametric flow cytometry was used for immunophenotyping. Results FAE s significantly reduced the numbers of CD 4 + T, CD 8 + T, CD 19 + B and CD 56 + NK cells. Among lymphocyte subsets, the mean percentage reduction from baseline was always highest for CD 8 + T cells, with a peak of 55.7% after 2 years of therapy. The risk of T‐cell lymphopenia increased significantly with the age of the psoriasis patients at the time that FAE therapy was initiated. It was significantly decreased for the combination therapy with methotrexate and folic acid (vitamin B9) supplementation. Supporting evidence was found suggesting that T‐cell lymphopenia enhances the effectiveness of FAE therapy. Conclusions Monitoring distinct T‐cell subsets rather than just absolute lymphocyte counts may provide more meaningful insights into both the FAE treatment safety and efficacy. We therefore suggest optimizing pharmacovigilance by additionally monitoring CD 4 + and CD 8 + T‐cell counts at regular intervals, especially in patients of middle to older age. Thus, further prospective studies are needed to establish evidence‐based recommendations to guide dermatologists in the management of psoriasis patients who are taking FAE s and who develop low absolute T‐cell counts." @default.
• W2912505315 created "2019-02-21" @default.
• W2912505315 creator A5005024943 @default.
• W2912505315 creator A5006074498 @default.
• W2912505315 creator A5019960294 @default.
• W2912505315 creator A5033573444 @default.
• W2912505315 creator A5034397660 @default.
• W2912505315 creator A5063479214 @default.
• W2912505315 date "2019-02-28" @default.
• W2912505315 modified "2023-09-27" @default.
• W2912505315 title "Fumaric acid ester‐induced T‐cell lymphopenia in the real‐life treatment of psoriasis" @default.
• W2912505315 cites W111647072 @default.
• W2912505315 cites W1517095095 @default.
• W2912505315 cites W1570676254 @default.
• W2912505315 cites W1757411051 @default.
• W2912505315 cites W1833317072 @default.
• W2912505315 cites W1929419973 @default.
• W2912505315 cites W1953711947 @default.
• W2912505315 cites W1964737176 @default.
• W2912505315 cites W1969546360 @default.
• W2912505315 cites W1972597833 @default.
• W2912505315 cites W2000341835 @default.
• W2912505315 cites W2012585552 @default.
• W2912505315 cites W2025402168 @default.
• W2912505315 cites W2026277530 @default.
• W2912505315 cites W2027129171 @default.
• W2912505315 cites W2038699977 @default.
• W2912505315 cites W2039550404 @default.
• W2912505315 cites W2041200995 @default.
• W2912505315 cites W2045676810 @default.
• W2912505315 cites W2049610435 @default.
• W2912505315 cites W2050172669 @default.
• W2912505315 cites W2054655809 @default.
• W2912505315 cites W2067327580 @default.
• W2912505315 cites W2072829987 @default.
• W2912505315 cites W2073568014 @default.
• W2912505315 cites W2077284091 @default.
• W2912505315 cites W2082618741 @default.
• W2912505315 cites W2097170399 @default.
• W2912505315 cites W2097593378 @default.
• W2912505315 cites W2101616110 @default.
• W2912505315 cites W2114568887 @default.
• W2912505315 cites W2137960802 @default.
• W2912505315 cites W2138636269 @default.
• W2912505315 cites W2142655452 @default.
• W2912505315 cites W2150226897 @default.
• W2912505315 cites W2153193872 @default.
• W2912505315 cites W2153242844 @default.
• W2912505315 cites W2154641505 @default.
• W2912505315 cites W2155632521 @default.
• W2912505315 cites W2159605569 @default.
• W2912505315 cites W2160950838 @default.
• W2912505315 cites W2162636055 @default.
• W2912505315 cites W2205231349 @default.
• W2912505315 cites W2277663394 @default.
• W2912505315 cites W2287944627 @default.
• W2912505315 cites W2343323874 @default.
• W2912505315 cites W2396487794 @default.
• W2912505315 cites W2400748902 @default.
• W2912505315 cites W2417054233 @default.
• W2912505315 cites W2471897020 @default.
• W2912505315 cites W2586125488 @default.
• W2912505315 cites W2594894796 @default.
• W2912505315 cites W2597919924 @default.
• W2912505315 cites W2609394914 @default.
• W2912505315 cites W2612052367 @default.
• W2912505315 cites W2619143798 @default.
• W2912505315 cites W2751402816 @default.
• W2912505315 cites W2752721387 @default.
• W2912505315 cites W2758080771 @default.
• W2912505315 cites W2762189029 @default.
• W2912505315 cites W2769798415 @default.
• W2912505315 cites W2791048627 @default.
• W2912505315 cites W2791749859 @default.
• W2912505315 cites W2792645441 @default.
• W2912505315 cites W2794363653 @default.
• W2912505315 cites W2794616513 @default.
• W2912505315 cites W2794813666 @default.
• W2912505315 cites W2795256497 @default.
• W2912505315 cites W2799524808 @default.
• W2912505315 cites W2799615858 @default.
• W2912505315 cites W2799971001 @default.
• W2912505315 cites W2800377815 @default.
• W2912505315 cites W2800495103 @default.
• W2912505315 cites W2807246821 @default.
• W2912505315 cites W2808427344 @default.
• W2912505315 cites W2810728334 @default.
• W2912505315 cites W2820841600 @default.
• W2912505315 cites W2912035394 @default.
• W2912505315 cites W2918243308 @default.
• W2912505315 cites W4211077900 @default.
• W2912505315 cites W4293241248 @default.
• W2912505315 cites W3150234214 @default.
• W2912505315 doi "https://doi.org/10.1111/jdv.15448" @default.
• W2912505315 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6593701" @default.
• W2912505315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30680823" @default.
• W2912505315 hasPublicationYear "2019" @default.
• W2912505315 type Work @default.

• next