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• W2912505923 abstract "Female Aedes aegypti mosquitoes bite humans to obtain blood to develop their eggs. Remarkably, their strong attraction to humans is suppressed for days after the blood meal by an unknown mechanism. We investigated a role for neuropeptide Y (NPY)-related signaling in long-term behavioral suppression and discovered that drugs targeting human NPY receptors modulate mosquito host-seeking. In a screen of all 49 predicted Ae. aegypti peptide receptors, we identified NPY-like receptor 7 (NPYLR7) as the sole target of these drugs. To obtain small-molecule agonists selective for NPYLR7, we performed a high-throughput cell-based assay of 265,211 compounds and isolated six highly selective NPYLR7 agonists that inhibit mosquito attraction to humans. NPYLR7 CRISPR-Cas9 null mutants are defective in behavioral suppression and resistant to these drugs. Finally, we show that these drugs can inhibit biting and blood-feeding on a live host, suggesting a novel approach to control infectious disease transmission by controlling mosquito behavior.Video AbstracteyJraWQiOiI4ZjUxYWNhY2IzYjhiNjNlNzFlYmIzYWFmYTU5NmZmYyIsImFsZyI6IlJTMjU2In0.eyJzdWIiOiJjZGQ0ODkyMTY5YWZhZDcyOWFjMGM2NzZkNTQyZGE1YyIsImtpZCI6IjhmNTFhY2FjYjNiOGI2M2U3MWViYjNhYWZhNTk2ZmZjIiwiZXhwIjoxNjc4NTU0NzMyfQ.IWqIlOv-k_s5VeH8vGctMuo6d2wnVQraplkJ0BqNeSWpc9I1CuK41HdQ7D0Y6zjDHGcYmCbA6N0lcR7GhcwcYlJktBF9CHD5koGyOMgn6PpFoexqUY5L9_rheIMShGWZjfq-W2eu99JcPhHcNOXLQ3nI54um-tcAKtPkF34pXJyOtVpX82kWquECPon_feVDg7YME6Znl4oyzekjKhsJzRBOO9-7XghUE78QjO2glylQt-WovwhdjdTuq8lpd2U5XEezFwsr68oTZaENO_q4uDjfzWNPOlJwE84dhLxMJYbGEIoehrmIgjzRsefINHApB-S0Y68C00Y3CXXoaHvtUw(mp4, (16.2 MB) Download video" @default.
• W2912505923 created "2019-02-21" @default.
• W2912505923 creator A5044501301 @default.
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• W2912505923 date "2019-02-01" @default.
• W2912505923 modified "2023-10-15" @default.
• W2912505923 title "Small-Molecule Agonists of Ae. aegypti Neuropeptide Y Receptor Block Mosquito Biting" @default.
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• W2912505923 doi "https://doi.org/10.1016/j.cell.2018.12.004" @default.
• W2912505923 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6369589" @default.
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• W2912505923 hasPublicationYear "2019" @default.
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