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- W2912506081 abstract "Synaptic vesicles fuse with the plasma membrane to release neurotransmitter both synchronously and asynchronously following an action potential. How many vesicles can fuse at a single active zone, and where these vesicles fuse within the active zone, is not well understood, particularly in the context of these two phases. To capture synaptic vesicle exocytosis during synchronous and asynchronous release at cultured mouse hippocampal synapses, we induced single action potentials (AP) by electrical field stimulation then subjected neurons to high-pressure freezing to examine their morphology by electron microscopy. During synchronous release (<5 ms after AP) multiple vesicles can fuse at a single active zone; this multivesicular release is augmented by increasing the extracellular calcium concentration. Synchronous fusions are distributed throughout the active zone, whereas asynchronous fusions (5-11 ms after AP) are biased toward the center of the active zone. As exocytosis proceeds, new vesicles are recruited to the active zone and fully replenish the docked pool, but docking of these vesicles is transient and they either undock or fuse within 100 ms. These results demonstrate that multivesicular release occurs even at low-release-probability synapses and suggest a spatial organization underlying synchronous and asynchronous release." @default.
- W2912506081 created "2019-02-21" @default.
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- W2912506081 date "2019-02-01" @default.
- W2912506081 modified "2023-09-30" @default.
- W2912506081 title "Synaptic Vesicle Fusion and Docking during the First 14 Milliseconds After an Action Potential" @default.
- W2912506081 doi "https://doi.org/10.1016/j.bpj.2018.11.2838" @default.
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