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- W2912507926 abstract "Acetaminophen (1 and 2 g.), salicylamide (1 g.), and 1 g. acetaminophen followed 1.5 hr. later by 1 or 2 g. salicylamide were administered in aqueous solutions to healthy human subjects. Urine was collected every 15-30 min. for the first 4-5 hr. and then at longer intervals. The urine samples were analyzed for acetaminophen, acetaminophen sulfate, acetaminophen glucuronide, salicylamide, salicylamide sulfate, and salicylamide glucuronide. The excretion rates of acetaminophen sulfate and acetaminophen glucuronide decreased immediately after administration of salicylamide. Acetaminophen decreased the formation of salicylamide sulfate. Coadministration of L-cysteine (a source of sulfate) prevented this effect and also increased the excretion of acetaminophen sulfate. The results indicate a competitive inhibition in the formation of acetaminophen sulfate and salicylamide sulfate and suggest also a competitive inhibition in the formation of acetaminophen glucuronide and salicylamide glucuronide." @default.
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- W2912507926 date "1971-02-01" @default.
- W2912507926 modified "2023-09-29" @default.
- W2912507926 title "Drug Biotransformation Interactions in Man III: Acetaminophen and Salicylamide" @default.
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- W2912507926 doi "https://doi.org/10.1002/jps.2600600212" @default.
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