Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912508324> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2912508324 endingPage "464" @default.
- W2912508324 startingPage "464" @default.
- W2912508324 abstract "Accelerated repetitive transcranial magnetic stimulation (rTMS) paradigms are currently used to improve treatment in major depressive disorder (MDD). Although these new treatment algorithms seem to be able to alleviate mood over a relatively short period of time, days instead of weeks, neuronal changes regarding clinical outcome remain unclear. We extensively evaluated the effects of two accelerated rTMS protocols on brain processing related to clinical outcome. 1H MR spectroscopy showed no negative influences on neuronal integrity; however, clinical improvement was related to significant GABA increases in the left DLPFC, suggesting impact on the stress system. Like other antidepressant treatments, beneficial outcome resulted in metabolic decreases in the subgenual cingulate cortex (sgACC). Functional connectivity changes between the sgACC and the (orbito)prefrontal regions showed not only to be of the essence for the antidepressant response but also to negative thinking styles. Moreover, after placebo accelerated iTBS, frontopolar prefrontal perfusion decreases, were accompanied by a significant attenuation of suicide ideation. Finally, connectome analyses showed that more densely interconnected regions, especially when actively stimulated, may be of essence to explain the clinical improvement, already present after 4 days of accelerated neurostimulation. Accelerated stimulation paradigms seem to be safe, and the effects on the brain -already present after just a few days of stimulation - are conform the neurobiological effects found with other antidepressant treatment modalities." @default.
- W2912508324 created "2019-02-21" @default.
- W2912508324 creator A5026672890 @default.
- W2912508324 date "2019-03-01" @default.
- W2912508324 modified "2023-10-18" @default.
- W2912508324 title "Accelerated neurostimulation in major depression: insights from brain imaging" @default.
- W2912508324 doi "https://doi.org/10.1016/j.brs.2018.12.511" @default.
- W2912508324 hasPublicationYear "2019" @default.
- W2912508324 type Work @default.
- W2912508324 sameAs 2912508324 @default.
- W2912508324 citedByCount "1" @default.
- W2912508324 countsByYear W29125083242022 @default.
- W2912508324 crossrefType "journal-article" @default.
- W2912508324 hasAuthorship W2912508324A5026672890 @default.
- W2912508324 hasConcept C118552586 @default.
- W2912508324 hasConcept C126322002 @default.
- W2912508324 hasConcept C139719470 @default.
- W2912508324 hasConcept C15744967 @default.
- W2912508324 hasConcept C162324750 @default.
- W2912508324 hasConcept C169760540 @default.
- W2912508324 hasConcept C169900460 @default.
- W2912508324 hasConcept C24998067 @default.
- W2912508324 hasConcept C2776443511 @default.
- W2912508324 hasConcept C2776867660 @default.
- W2912508324 hasConcept C2777342061 @default.
- W2912508324 hasConcept C2778402161 @default.
- W2912508324 hasConcept C2778542668 @default.
- W2912508324 hasConcept C2778581513 @default.
- W2912508324 hasConcept C2779134260 @default.
- W2912508324 hasConcept C2779144063 @default.
- W2912508324 hasConcept C2779177272 @default.
- W2912508324 hasConcept C2779734285 @default.
- W2912508324 hasConcept C2780051608 @default.
- W2912508324 hasConcept C2780375056 @default.
- W2912508324 hasConcept C2780508717 @default.
- W2912508324 hasConcept C2780733359 @default.
- W2912508324 hasConcept C2781161787 @default.
- W2912508324 hasConcept C2781195155 @default.
- W2912508324 hasConcept C71924100 @default.
- W2912508324 hasConceptScore W2912508324C118552586 @default.
- W2912508324 hasConceptScore W2912508324C126322002 @default.
- W2912508324 hasConceptScore W2912508324C139719470 @default.
- W2912508324 hasConceptScore W2912508324C15744967 @default.
- W2912508324 hasConceptScore W2912508324C162324750 @default.
- W2912508324 hasConceptScore W2912508324C169760540 @default.
- W2912508324 hasConceptScore W2912508324C169900460 @default.
- W2912508324 hasConceptScore W2912508324C24998067 @default.
- W2912508324 hasConceptScore W2912508324C2776443511 @default.
- W2912508324 hasConceptScore W2912508324C2776867660 @default.
- W2912508324 hasConceptScore W2912508324C2777342061 @default.
- W2912508324 hasConceptScore W2912508324C2778402161 @default.
- W2912508324 hasConceptScore W2912508324C2778542668 @default.
- W2912508324 hasConceptScore W2912508324C2778581513 @default.
- W2912508324 hasConceptScore W2912508324C2779134260 @default.
- W2912508324 hasConceptScore W2912508324C2779144063 @default.
- W2912508324 hasConceptScore W2912508324C2779177272 @default.
- W2912508324 hasConceptScore W2912508324C2779734285 @default.
- W2912508324 hasConceptScore W2912508324C2780051608 @default.
- W2912508324 hasConceptScore W2912508324C2780375056 @default.
- W2912508324 hasConceptScore W2912508324C2780508717 @default.
- W2912508324 hasConceptScore W2912508324C2780733359 @default.
- W2912508324 hasConceptScore W2912508324C2781161787 @default.
- W2912508324 hasConceptScore W2912508324C2781195155 @default.
- W2912508324 hasConceptScore W2912508324C71924100 @default.
- W2912508324 hasIssue "2" @default.
- W2912508324 hasLocation W29125083241 @default.
- W2912508324 hasOpenAccess W2912508324 @default.
- W2912508324 hasPrimaryLocation W29125083241 @default.
- W2912508324 hasRelatedWork W1968935562 @default.
- W2912508324 hasRelatedWork W2041565742 @default.
- W2912508324 hasRelatedWork W2129870118 @default.
- W2912508324 hasRelatedWork W2324159670 @default.
- W2912508324 hasRelatedWork W2486680632 @default.
- W2912508324 hasRelatedWork W2589341022 @default.
- W2912508324 hasRelatedWork W2810195025 @default.
- W2912508324 hasRelatedWork W2910282940 @default.
- W2912508324 hasRelatedWork W2984101019 @default.
- W2912508324 hasRelatedWork W4296295693 @default.
- W2912508324 hasVolume "12" @default.
- W2912508324 isParatext "false" @default.
- W2912508324 isRetracted "false" @default.
- W2912508324 magId "2912508324" @default.
- W2912508324 workType "article" @default.