FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912509459> ?p ?o ?g. }

• W2912509459 endingPage "3677" @default.
• W2912509459 startingPage "3668" @default.
• W2912509459 abstract "Histones are modified by enzymes that act in a locus, cell-type, and developmental stage-specific manner. The recruitment of enzymes to chromatin is regulated at multiple levels, including interaction with sequence-specific DNA-binding factors. However, the DNA-binding specificity of the regulatory factors that orchestrate specific histone modifications has not been broadly mapped. We have analyzed 6 histone marks (H3K4me1, H3K4me3, H3K27ac, H3K27me3, K3H9me3, H3K36me3) across 121 human cell types and tissues from the NIH Roadmap Epigenomics Project as well as 8 histone marks (with addition of H3K4me2 and H3K9ac) from the mouse ENCODE Consortium. We have identified 361 and 369 DNA motifs in human and mouse, respectively, that are the most predictive of each histone mark. Interestingly, 107 human motifs are conserved between the two species. In human embryonic cell line H1, we mutated only the found DNA motifs at particular loci and the significant reduction of H3K27ac levels validated the regulatory roles of the perturbed motifs. The functionality of these motifs was also supported by the evidence that histone-associated motifs, especially H3K4me3 motifs, significantly overlap with the expression of quantitative trait loci SNPs in cancer patients more than the known and random motifs. Furthermore, we observed possible feedbacks to control chromatin dynamics as the found motifs appear in the promoters or enhancers associated with various histone modification enzymes. These results pave the way toward revealing the molecular mechanisms of epigenetic events, such as histone modification dynamics and epigenetic priming." @default.
• W2912509459 created "2019-02-21" @default.
• W2912509459 creator A5001358993 @default.
• W2912509459 creator A5003850660 @default.
• W2912509459 creator A5022924777 @default.
• W2912509459 creator A5046597133 @default.
• W2912509459 creator A5086960659 @default.
• W2912509459 creator A5091735498 @default.
• W2912509459 date "2019-02-12" @default.
• W2912509459 modified "2023-10-17" @default.
• W2912509459 title "Epigenomic analysis reveals DNA motifs regulating histone modifications in human and mouse" @default.
• W2912509459 cites W1979594866 @default.
• W2912509459 cites W1979841601 @default.
• W2912509459 cites W1982881824 @default.
• W2912509459 cites W1985063313 @default.
• W2912509459 cites W1986586739 @default.
• W2912509459 cites W1990699073 @default.
• W2912509459 cites W1991543373 @default.
• W2912509459 cites W1996826230 @default.
• W2912509459 cites W1999491723 @default.
• W2912509459 cites W2009720434 @default.
• W2912509459 cites W2017390554 @default.
• W2912509459 cites W2076154138 @default.
• W2912509459 cites W2081418555 @default.
• W2912509459 cites W2088170764 @default.
• W2912509459 cites W2089200494 @default.
• W2912509459 cites W2099085143 @default.
• W2912509459 cites W2100697281 @default.
• W2912509459 cites W2103777723 @default.
• W2912509459 cites W2104549677 @default.
• W2912509459 cites W2119608842 @default.
• W2912509459 cites W2122796505 @default.
• W2912509459 cites W2134868027 @default.
• W2912509459 cites W2142136518 @default.
• W2912509459 cites W2145191876 @default.
• W2912509459 cites W2158485828 @default.
• W2912509459 cites W2171808845 @default.
• W2912509459 cites W2212528563 @default.
• W2912509459 cites W2786141666 @default.
• W2912509459 cites W370702354 @default.
• W2912509459 doi "https://doi.org/10.1073/pnas.1813565116" @default.
• W2912509459 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6397554" @default.
• W2912509459 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30755522" @default.
• W2912509459 hasPublicationYear "2019" @default.
• W2912509459 type Work @default.
• W2912509459 sameAs 2912509459 @default.
• W2912509459 citedByCount "32" @default.
• W2912509459 countsByYear W29125094592019 @default.
• W2912509459 countsByYear W29125094592020 @default.
• W2912509459 countsByYear W29125094592021 @default.
• W2912509459 countsByYear W29125094592022 @default.
• W2912509459 countsByYear W29125094592023 @default.
• W2912509459 crossrefType "journal-article" @default.
• W2912509459 hasAuthorship W2912509459A5001358993 @default.
• W2912509459 hasAuthorship W2912509459A5003850660 @default.
• W2912509459 hasAuthorship W2912509459A5022924777 @default.
• W2912509459 hasAuthorship W2912509459A5046597133 @default.
• W2912509459 hasAuthorship W2912509459A5086960659 @default.
• W2912509459 hasAuthorship W2912509459A5091735498 @default.
• W2912509459 hasBestOaLocation W29125094591 @default.
• W2912509459 hasConcept C10058791 @default.
• W2912509459 hasConcept C101762097 @default.
• W2912509459 hasConcept C104317684 @default.
• W2912509459 hasConcept C121912465 @default.
• W2912509459 hasConcept C150194340 @default.
• W2912509459 hasConcept C190727270 @default.
• W2912509459 hasConcept C22709980 @default.
• W2912509459 hasConcept C2780914512 @default.
• W2912509459 hasConcept C41091548 @default.
• W2912509459 hasConcept C54355233 @default.
• W2912509459 hasConcept C552990157 @default.
• W2912509459 hasConcept C64927066 @default.
• W2912509459 hasConcept C70721500 @default.
• W2912509459 hasConcept C83640560 @default.
• W2912509459 hasConcept C84772758 @default.
• W2912509459 hasConcept C86803240 @default.
• W2912509459 hasConceptScore W2912509459C10058791 @default.
• W2912509459 hasConceptScore W2912509459C101762097 @default.
• W2912509459 hasConceptScore W2912509459C104317684 @default.
• W2912509459 hasConceptScore W2912509459C121912465 @default.
• W2912509459 hasConceptScore W2912509459C150194340 @default.
• W2912509459 hasConceptScore W2912509459C190727270 @default.
• W2912509459 hasConceptScore W2912509459C22709980 @default.
• W2912509459 hasConceptScore W2912509459C2780914512 @default.
• W2912509459 hasConceptScore W2912509459C41091548 @default.
• W2912509459 hasConceptScore W2912509459C54355233 @default.
• W2912509459 hasConceptScore W2912509459C552990157 @default.
• W2912509459 hasConceptScore W2912509459C64927066 @default.
• W2912509459 hasConceptScore W2912509459C70721500 @default.
• W2912509459 hasConceptScore W2912509459C83640560 @default.
• W2912509459 hasConceptScore W2912509459C84772758 @default.
• W2912509459 hasConceptScore W2912509459C86803240 @default.
• W2912509459 hasIssue "9" @default.
• W2912509459 hasLocation W29125094591 @default.
• W2912509459 hasLocation W29125094592 @default.
• W2912509459 hasLocation W29125094593 @default.
• W2912509459 hasLocation W29125094594 @default.
• W2912509459 hasOpenAccess W2912509459 @default.

• next