FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912521584> ?p ?o ?g. }

• W2912521584 endingPage "124" @default.
• W2912521584 startingPage "111" @default.
• W2912521584 abstract "The solute transport distribution in a tumor is an important criterion in the evaluation of the cancer treatment efficacy. The fraction of killed cells after each treatment can quantify the therapeutic effect and plays as a helpful tool to evaluate the chemotherapy treatment schedules. In the present study, an image-based spatio-temporal computational model of a solid tumor is provided for calculation of interstitial fluid flow and solute transport. Current model incorporates heterogeneous microvasculature for angiogenesis instead of synthetic mathematical modeling. In this modeling process, a comprehensive model according to Convection-Diffusion-Reaction (CDR) equations is employed due to its high accuracy for simulating the binding and the uptake of the drug by tumor cells. Based on the velocity and the pressure distribution, transient distribution of the different drug concentrations (free, bound, and internalized) is calculated. Then, the fraction of killed cells is obtained according to the internalized concentration. Results indicate the dependence of the drug distribution on both time and space, as well as the microvasculature density. Free and bound drug concentration have the same trend over time, whereas, internalized and total drug concentration increases over time and reaches a constant value. The highest amount of concentration occurred in the tumor region due to the higher permeability of the blood vessels. Moreover, the fraction of killed cells is approximately 78.87% and 24.94% after treatment with doxorubicin for cancerous and normal tissues, respectively. In general, the presented methodology may be applied in the field of personalized medicine to optimize patient-specific treatments. Also, such image-based modeling of solid tumors can be used in laboratories that working on drug delivery and evaluating new drugs before using them for any in vivo or clinical studies." @default.
• W2912521584 created "2019-02-21" @default.
• W2912521584 creator A5012909468 @default.
• W2912521584 creator A5026042311 @default.
• W2912521584 creator A5026191305 @default.
• W2912521584 creator A5047303926 @default.
• W2912521584 creator A5082883247 @default.
• W2912521584 date "2019-05-01" @default.
• W2912521584 modified "2023-10-13" @default.
• W2912521584 title "Image-based spatio-temporal model of drug delivery in a heterogeneous vasculature of a solid tumor — Computational approach" @default.
• W2912521584 cites W1023185203 @default.
• W2912521584 cites W1504011557 @default.
• W2912521584 cites W1964128680 @default.
• W2912521584 cites W1978550123 @default.
• W2912521584 cites W1981731521 @default.
• W2912521584 cites W1982369490 @default.
• W2912521584 cites W1987060944 @default.
• W2912521584 cites W1987451510 @default.
• W2912521584 cites W2000499349 @default.
• W2912521584 cites W2007988714 @default.
• W2912521584 cites W2009347528 @default.
• W2912521584 cites W2021348527 @default.
• W2912521584 cites W2036048176 @default.
• W2912521584 cites W2041337540 @default.
• W2912521584 cites W2042849303 @default.
• W2912521584 cites W2048195900 @default.
• W2912521584 cites W2048556470 @default.
• W2912521584 cites W2052672777 @default.
• W2912521584 cites W2055384999 @default.
• W2912521584 cites W2066724170 @default.
• W2912521584 cites W2068930618 @default.
• W2912521584 cites W2082498763 @default.
• W2912521584 cites W2086567692 @default.
• W2912521584 cites W2090526063 @default.
• W2912521584 cites W2106979625 @default.
• W2912521584 cites W2111454763 @default.
• W2912521584 cites W2128253222 @default.
• W2912521584 cites W2128765685 @default.
• W2912521584 cites W2137780330 @default.
• W2912521584 cites W2143203694 @default.
• W2912521584 cites W2148284840 @default.
• W2912521584 cites W2157084699 @default.
• W2912521584 cites W2166524747 @default.
• W2912521584 cites W2508533427 @default.
• W2912521584 cites W2517181214 @default.
• W2912521584 cites W2560755587 @default.
• W2912521584 cites W2586409664 @default.
• W2912521584 cites W2586781596 @default.
• W2912521584 cites W2752282573 @default.
• W2912521584 cites W2767780867 @default.
• W2912521584 cites W2771162107 @default.
• W2912521584 cites W2775867286 @default.
• W2912521584 cites W2781054980 @default.
• W2912521584 cites W2792665263 @default.
• W2912521584 cites W2793869682 @default.
• W2912521584 cites W2795256563 @default.
• W2912521584 cites W2801138230 @default.
• W2912521584 cites W2925166362 @default.
• W2912521584 cites W3125067599 @default.
• W2912521584 cites W4244061122 @default.
• W2912521584 cites W4376453924 @default.
• W2912521584 doi "https://doi.org/10.1016/j.mvr.2019.01.005" @default.
• W2912521584 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30711547" @default.
• W2912521584 hasPublicationYear "2019" @default.
• W2912521584 type Work @default.
• W2912521584 sameAs 2912521584 @default.
• W2912521584 citedByCount "51" @default.
• W2912521584 countsByYear W29125215842019 @default.
• W2912521584 countsByYear W29125215842020 @default.
• W2912521584 countsByYear W29125215842021 @default.
• W2912521584 countsByYear W29125215842022 @default.
• W2912521584 countsByYear W29125215842023 @default.
• W2912521584 crossrefType "journal-article" @default.
• W2912521584 hasAuthorship W2912521584A5012909468 @default.
• W2912521584 hasAuthorship W2912521584A5026042311 @default.
• W2912521584 hasAuthorship W2912521584A5026191305 @default.
• W2912521584 hasAuthorship W2912521584A5047303926 @default.
• W2912521584 hasAuthorship W2912521584A5082883247 @default.
• W2912521584 hasBestOaLocation W29125215842 @default.
• W2912521584 hasConcept C110121322 @default.
• W2912521584 hasConcept C112705442 @default.
• W2912521584 hasConcept C113045295 @default.
• W2912521584 hasConcept C120882062 @default.
• W2912521584 hasConcept C12554922 @default.
• W2912521584 hasConcept C134306372 @default.
• W2912521584 hasConcept C136229726 @default.
• W2912521584 hasConcept C141071460 @default.
• W2912521584 hasConcept C142724271 @default.
• W2912521584 hasConcept C150489694 @default.
• W2912521584 hasConcept C158846371 @default.
• W2912521584 hasConcept C164705383 @default.
• W2912521584 hasConcept C171250308 @default.
• W2912521584 hasConcept C185592680 @default.
• W2912521584 hasConcept C186060115 @default.
• W2912521584 hasConcept C192562407 @default.
• W2912521584 hasConcept C2776694085 @default.
• W2912521584 hasConcept C2779820397 @default.
• W2912521584 hasConcept C2780035454 @default.

• next