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- W2912522076 endingPage "1081.e3" @default.
- W2912522076 startingPage "1073" @default.
- W2912522076 abstract "It is generally thought that hippocampal neurons of perinatal rats and mice lack transport-functional K-Cl cotransporter KCC2, and that Cl- regulation is dominated by Cl- uptake via the Na-K-2Cl cotransporter NKCC1. Here, we demonstrate a robust enhancement of spontaneous hippocampal network events (giant depolarizing potentials [GDPs]) by the KCC2 inhibitor VU0463271 in neonatal rats and late-gestation, wild-type mouse embryos, but not in their KCC2-null littermates. VU0463271 increased the depolarizing GABAergic synaptic drive onto neonatal CA3 pyramidal neurons, increasing their spiking probability and synchrony during the rising phase of a GDP. Our data indicate that Cl- extrusion by KCC2 is involved in modulation of GDPs already at their developmental onset during the perinatal period in mice and rats." @default.
- W2912522076 created "2019-02-21" @default.
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- W2912522076 date "2019-01-01" @default.
- W2912522076 modified "2023-10-12" @default.
- W2912522076 title "KCC2-Mediated Cl− Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice" @default.
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- W2912522076 doi "https://doi.org/10.1016/j.celrep.2019.01.011" @default.
- W2912522076 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6352714" @default.
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- W2912522076 hasPublicationYear "2019" @default.
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