FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912523030> ?p ?o ?g. }

• W2912523030 endingPage "69" @default.
• W2912523030 startingPage "60" @default.
• W2912523030 abstract "In this study, the Mycobacterium tuberculosis (MTB) latency-associated antigens Rv2660c, Rv1733c, Rv1813c, Rv2628, Rv2029c, and Rv2659c were compared regarding their immunogenicity and potential therapeutic effects in an MTB reactivation mouse model. Normal mice or MTB reactivation mice were immunized intramuscularly three times at 2-week intervals with saline, plasmid vector pVAX1, Mycobacterium vaccae vaccine (a commercial inactivated vaccine), rv1813c DNA, rv2628 DNA, rv2029c DNA, rv2659c DNA, rv1733c DNA, or rv2660c DNA. The normal mice immunized with rv2628 DNA or rv2659c DNA had low numbers of Th1 cells and a lower ratio of Th1:Th2 immune cells in whole blood (p < 0.05). Compared to the saline group, Tc1 cells in the rv2029c DNA group and Tc1:Tc2 cell ratio in the rv1813c DNA, rv2628 DNA, and rv2029c DNA groups were significantly decreased (p < 0.05). The proportion of Foxp3+CD4+ T cells in the rv2628 DNA and rv2659c DNA groups and the proportion of CD4+CD25+ T cells in the rv2029c DNA group were significantly increased (p < 0.05). The level of anti-Rv1813c-immunoglobulin G (IgG) in the rv1813c DNA group was significantly increased (p < 0.01). The levels of specific IgG, IgG1, and IgG2a in the rv2628 DNA, rv2029c DNA, and rv2659c DNA groups were significantly increased (p < 0.05). Lung colony-forming units in M. vaccae and the six DNA groups decreased to different degrees in the MTB reactivation mouse model, but only the lung colony-forming units in the rv2628 DNA group (4.38 ± 0.70 log10) significantly decreased compared to the vector group (5.90 ± 0.42 log10; p < 0.05). The MTB rv1813c DNA, rv2628 DNA, rv2029c DNA, and rv2659c DNA could elicit a strong humoral immune response and a higher proportion of CD4+CD25+or CD4+Foxp3+ T cells but could not increase the proportions of Th1 and Tc1 cells. These results suggest that latency-associated DNA vaccines, especially rv2628 DNA, had some therapeutic effect on the endogenous resurgence mouse tuberculosis model." @default.
• W2912523030 created "2019-02-21" @default.
• W2912523030 creator A5021636467 @default.
• W2912523030 creator A5023360597 @default.
• W2912523030 creator A5028859676 @default.
• W2912523030 creator A5039749701 @default.
• W2912523030 creator A5063800558 @default.
• W2912523030 creator A5072109135 @default.
• W2912523030 creator A5072895406 @default.
• W2912523030 creator A5075877965 @default.
• W2912523030 creator A5081600756 @default.
• W2912523030 creator A5083455588 @default.
• W2912523030 creator A5084072260 @default.
• W2912523030 creator A5088734670 @default.
• W2912523030 creator A5089812245 @default.
• W2912523030 creator A5091820672 @default.
• W2912523030 date "2019-04-01" @default.
• W2912523030 modified "2023-10-06" @default.
• W2912523030 title "Immunogenicity and Therapeutic Effects of Latency-Associated Genes in a <i>Mycobacterium Tuberculosis</i> Reactivation Mouse Model" @default.
• W2912523030 cites W1533908903 @default.
• W2912523030 cites W1543888238 @default.
• W2912523030 cites W1591224424 @default.
• W2912523030 cites W1966820980 @default.
• W2912523030 cites W1970021707 @default.
• W2912523030 cites W1975223125 @default.
• W2912523030 cites W1977872791 @default.
• W2912523030 cites W1991136227 @default.
• W2912523030 cites W2019993409 @default.
• W2912523030 cites W2026709385 @default.
• W2912523030 cites W2035288424 @default.
• W2912523030 cites W2048961513 @default.
• W2912523030 cites W2052746704 @default.
• W2912523030 cites W2063679726 @default.
• W2912523030 cites W2067648924 @default.
• W2912523030 cites W2069014426 @default.
• W2912523030 cites W2077080767 @default.
• W2912523030 cites W2080581800 @default.
• W2912523030 cites W2083602561 @default.
• W2912523030 cites W2099183065 @default.
• W2912523030 cites W2100337838 @default.
• W2912523030 cites W2105366441 @default.
• W2912523030 cites W2105863831 @default.
• W2912523030 cites W2109484445 @default.
• W2912523030 cites W2118868279 @default.
• W2912523030 cites W2125112523 @default.
• W2912523030 cites W2128013710 @default.
• W2912523030 cites W2130046741 @default.
• W2912523030 cites W2132286842 @default.
• W2912523030 cites W2144010669 @default.
• W2912523030 cites W2157737997 @default.
• W2912523030 cites W2172084836 @default.
• W2912523030 cites W2199686236 @default.
• W2912523030 cites W2554153257 @default.
• W2912523030 cites W2606388640 @default.
• W2912523030 doi "https://doi.org/10.1089/hgtb.2018.211" @default.
• W2912523030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30727774" @default.
• W2912523030 hasPublicationYear "2019" @default.
• W2912523030 type Work @default.
• W2912523030 sameAs 2912523030 @default.
• W2912523030 citedByCount "9" @default.
• W2912523030 countsByYear W29125230302019 @default.
• W2912523030 countsByYear W29125230302021 @default.
• W2912523030 countsByYear W29125230302022 @default.
• W2912523030 countsByYear W29125230302023 @default.
• W2912523030 crossrefType "journal-article" @default.
• W2912523030 hasAuthorship W2912523030A5021636467 @default.
• W2912523030 hasAuthorship W2912523030A5023360597 @default.
• W2912523030 hasAuthorship W2912523030A5028859676 @default.
• W2912523030 hasAuthorship W2912523030A5039749701 @default.
• W2912523030 hasAuthorship W2912523030A5063800558 @default.
• W2912523030 hasAuthorship W2912523030A5072109135 @default.
• W2912523030 hasAuthorship W2912523030A5072895406 @default.
• W2912523030 hasAuthorship W2912523030A5075877965 @default.
• W2912523030 hasAuthorship W2912523030A5081600756 @default.
• W2912523030 hasAuthorship W2912523030A5083455588 @default.
• W2912523030 hasAuthorship W2912523030A5084072260 @default.
• W2912523030 hasAuthorship W2912523030A5088734670 @default.
• W2912523030 hasAuthorship W2912523030A5089812245 @default.
• W2912523030 hasAuthorship W2912523030A5091820672 @default.
• W2912523030 hasConcept C147483822 @default.
• W2912523030 hasConcept C153911025 @default.
• W2912523030 hasConcept C159047783 @default.
• W2912523030 hasConcept C167508917 @default.
• W2912523030 hasConcept C195856716 @default.
• W2912523030 hasConcept C203014093 @default.
• W2912523030 hasConcept C22744801 @default.
• W2912523030 hasConcept C2780801004 @default.
• W2912523030 hasConcept C2780868878 @default.
• W2912523030 hasConcept C54355233 @default.
• W2912523030 hasConcept C552990157 @default.
• W2912523030 hasConcept C86803240 @default.
• W2912523030 hasConcept C8891405 @default.
• W2912523030 hasConceptScore W2912523030C147483822 @default.
• W2912523030 hasConceptScore W2912523030C153911025 @default.
• W2912523030 hasConceptScore W2912523030C159047783 @default.
• W2912523030 hasConceptScore W2912523030C167508917 @default.
• W2912523030 hasConceptScore W2912523030C195856716 @default.
• W2912523030 hasConceptScore W2912523030C203014093 @default.

• next