FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912533079> ?p ?o ?g. }

• W2912533079 endingPage "20180076" @default.
• W2912533079 startingPage "20180076" @default.
• W2912533079 abstract "Cholera toxin (CT) is a secreted bacterial toxin that binds to glycoconjugate receptors on the surface of mammalian cells, enters mammalian cells through endocytic mechanisms and intoxicates mammalian cells by activating cytosolic adenylate cyclase. CT recognizes cell surface receptors through its B subunit (CTB). While the ganglioside GM1 has been historically described as the sole receptor, CTB is also capable of binding to fucosylated glycoconjugates, and fucosylated molecules have been shown to play a functional role in host cell intoxication by CT. Here, we use colonic epithelial and respiratory epithelial cell lines to examine how two types of CT receptors—gangliosides and fucosylated glycoconjugates—contribute to CTB internalization. We show that fucosylated glycoconjugates contribute to CTB binding to and internalization into host cells, even when the ganglioside GM1 is present. The contributions of the two classes of receptors to CTB internalization depend on cell type. Additionally, in a cell line that harbours both classes of receptors, gangliosides dictate the efficiency of CTB internalization. Together, the results lend support to the idea that fucosylated glycoconjugates play a functional role in CTB internalization, and suggest that CT internalization depends on both receptor identity and cell type." @default.
• W2912533079 created "2019-02-21" @default.
• W2912533079 creator A5021808390 @default.
• W2912533079 creator A5047738067 @default.
• W2912533079 creator A5062428666 @default.
• W2912533079 creator A5065855868 @default.
• W2912533079 creator A5069020251 @default.
• W2912533079 creator A5082021869 @default.
• W2912533079 date "2019-02-15" @default.
• W2912533079 modified "2023-10-17" @default.
• W2912533079 title "Cell type and receptor identity regulate cholera toxin subunit B (CTB) internalization" @default.
• W2912533079 cites W1513638021 @default.
• W2912533079 cites W1885689715 @default.
• W2912533079 cites W1935374681 @default.
• W2912533079 cites W1978064025 @default.
• W2912533079 cites W1979560264 @default.
• W2912533079 cites W1979700521 @default.
• W2912533079 cites W1981154770 @default.
• W2912533079 cites W1982056508 @default.
• W2912533079 cites W1988285028 @default.
• W2912533079 cites W1996497544 @default.
• W2912533079 cites W1996828131 @default.
• W2912533079 cites W2014405796 @default.
• W2912533079 cites W2027770270 @default.
• W2912533079 cites W2030490593 @default.
• W2912533079 cites W2041367649 @default.
• W2912533079 cites W2052629150 @default.
• W2912533079 cites W2052691998 @default.
• W2912533079 cites W2067381924 @default.
• W2912533079 cites W2073031404 @default.
• W2912533079 cites W2085979150 @default.
• W2912533079 cites W2089505132 @default.
• W2912533079 cites W2090055664 @default.
• W2912533079 cites W2100630873 @default.
• W2912533079 cites W2113086326 @default.
• W2912533079 cites W2113523267 @default.
• W2912533079 cites W2114547141 @default.
• W2912533079 cites W2124864045 @default.
• W2912533079 cites W2146007591 @default.
• W2912533079 cites W2149985631 @default.
• W2912533079 cites W2153121397 @default.
• W2912533079 cites W2160599817 @default.
• W2912533079 cites W2170536614 @default.
• W2912533079 cites W2190652017 @default.
• W2912533079 cites W2211987955 @default.
• W2912533079 cites W2306594725 @default.
• W2912533079 cites W2342337884 @default.
• W2912533079 cites W2528396364 @default.
• W2912533079 cites W2658781598 @default.
• W2912533079 cites W2754806030 @default.
• W2912533079 cites W2786499096 @default.
• W2912533079 cites W2787740035 @default.
• W2912533079 cites W2795877570 @default.
• W2912533079 cites W2797154150 @default.
• W2912533079 cites W2808903874 @default.
• W2912533079 cites W4211099692 @default.
• W2912533079 doi "https://doi.org/10.1098/rsfs.2018.0076" @default.
• W2912533079 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6388018" @default.
• W2912533079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30842875" @default.
• W2912533079 hasPublicationYear "2019" @default.
• W2912533079 type Work @default.
• W2912533079 sameAs 2912533079 @default.
• W2912533079 citedByCount "23" @default.
• W2912533079 countsByYear W29125330792019 @default.
• W2912533079 countsByYear W29125330792020 @default.
• W2912533079 countsByYear W29125330792021 @default.
• W2912533079 countsByYear W29125330792022 @default.
• W2912533079 countsByYear W29125330792023 @default.
• W2912533079 crossrefType "journal-article" @default.
• W2912533079 hasAuthorship W2912533079A5021808390 @default.
• W2912533079 hasAuthorship W2912533079A5047738067 @default.
• W2912533079 hasAuthorship W2912533079A5062428666 @default.
• W2912533079 hasAuthorship W2912533079A5065855868 @default.
• W2912533079 hasAuthorship W2912533079A5069020251 @default.
• W2912533079 hasAuthorship W2912533079A5082021869 @default.
• W2912533079 hasBestOaLocation W29125330791 @default.
• W2912533079 hasConcept C13426554 @default.
• W2912533079 hasConcept C139770010 @default.
• W2912533079 hasConcept C170493617 @default.
• W2912533079 hasConcept C2777006276 @default.
• W2912533079 hasConcept C2777331542 @default.
• W2912533079 hasConcept C28005876 @default.
• W2912533079 hasConcept C54355233 @default.
• W2912533079 hasConcept C55493867 @default.
• W2912533079 hasConcept C79747257 @default.
• W2912533079 hasConcept C81885089 @default.
• W2912533079 hasConcept C86803240 @default.
• W2912533079 hasConcept C89423630 @default.
• W2912533079 hasConcept C95444343 @default.
• W2912533079 hasConceptScore W2912533079C13426554 @default.
• W2912533079 hasConceptScore W2912533079C139770010 @default.
• W2912533079 hasConceptScore W2912533079C170493617 @default.
• W2912533079 hasConceptScore W2912533079C2777006276 @default.
• W2912533079 hasConceptScore W2912533079C2777331542 @default.
• W2912533079 hasConceptScore W2912533079C28005876 @default.
• W2912533079 hasConceptScore W2912533079C54355233 @default.
• W2912533079 hasConceptScore W2912533079C55493867 @default.
• W2912533079 hasConceptScore W2912533079C79747257 @default.

• next