FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912534619> ?p ?o ?g. }

• W2912534619 abstract "Aims: We previously showed that the valosin containing protein (VCP), a member of ATPases associated protein, protects the heart against pressure overload induced cardiac hypertrophy and dysfunction in transgenic (TG) mice. The mechanisms remain unknown. We hypothesize that VCP regulated alteration in transcriptome contributes to its cardio-protection by targeting cardiac cell growth and survival. Methods and results: Cardiac-specific VCPTG mice and their litter-matched wild type (WT) mice were subjected to transverse aortic constriction (TAC) for 2 and 5 weeks and compared to the sham mice. By using echocardiography and hemodynamic analysis, cardiac hypertrophy and dysfunction were confirmed in 2 weeks- and 5 weeks- TAC models respectively in WT but not in VCPTG mice. Total RNA was extracted from left ventricular tissues and gene expression was determined by RNA-Seq transcriptome analysis. Upon 2 weeks TAC, 690 differentially expressed genes were identified between VCPTG and WT (Fold Change ≥ 1.5, P value ≤ 0.05). Among these genes, VCPTG TAC mice, compared to WT TAC mice, showed significant activation of the genes linked to transcriptional factors, Protein Kinase CGMP-Dependent Type I ( Prkg1 ) and Kruppel Like factor 15 ( Klf15 ), the known repressors of cardiac hypertrophy under stress. On the contrary, there is significant increase in cardiac hypertrophy associated genes in WT TAC mice, such as myosin light chain 7 ( Myl7 ), periostin ( Postn ) and tropomyosin beta chain ( Tpm2) , and in fetal gene natriuretic peptide A ( Nppa) , but these alterations were not observed in VCPTG TAC mice, which may contribute to repression of cardiac hypertrophy in VCPTG mice. In addition, pro-apoptosis genes, such as platelet factor 4 ( Pf4), Pleckstrin homology like domain A1 ( Phlda1 ) and Radical S-Adenosyl Methionine Domain Containing 2 ( Rsad2 ), are significantly downregulated continually in 2 weeks through 5 weeks TAC in VCPTG mice, but not in WT TAC, which may contribute to the protection of cell survival in VCPTG mice. Conclusion: Significant difference of gene regulation exists between VCPTG and WT in the heart under the pressure overload which may be the mechanism of VCP mediated cardiac protection." @default.
• W2912534619 created "2019-02-21" @default.
• W2912534619 creator A5020701449 @default.
• W2912534619 creator A5028462736 @default.
• W2912534619 creator A5067846239 @default.
• W2912534619 creator A5084068635 @default.
• W2912534619 creator A5088070159 @default.
• W2912534619 creator A5089548009 @default.
• W2912534619 date "2017-07-21" @default.
• W2912534619 modified "2023-09-23" @default.
• W2912534619 title "Abstract 107: RNA Seq Transcriptome Analysis Reveals Genes and Pathways Involved in the Cardiac Protection of VCP Against Pressure Overload" @default.
• W2912534619 doi "https://doi.org/10.1161/res.121.suppl_1.107" @default.
• W2912534619 hasPublicationYear "2017" @default.
• W2912534619 type Work @default.
• W2912534619 sameAs 2912534619 @default.
• W2912534619 citedByCount "0" @default.
• W2912534619 crossrefType "journal-article" @default.
• W2912534619 hasAuthorship W2912534619A5020701449 @default.
• W2912534619 hasAuthorship W2912534619A5028462736 @default.
• W2912534619 hasAuthorship W2912534619A5067846239 @default.
• W2912534619 hasAuthorship W2912534619A5084068635 @default.
• W2912534619 hasAuthorship W2912534619A5088070159 @default.
• W2912534619 hasAuthorship W2912534619A5089548009 @default.
• W2912534619 hasConcept C102230213 @default.
• W2912534619 hasConcept C104317684 @default.
• W2912534619 hasConcept C126322002 @default.
• W2912534619 hasConcept C134018914 @default.
• W2912534619 hasConcept C141035611 @default.
• W2912534619 hasConcept C150194340 @default.
• W2912534619 hasConcept C162317418 @default.
• W2912534619 hasConcept C167414201 @default.
• W2912534619 hasConcept C205875245 @default.
• W2912534619 hasConcept C2778069365 @default.
• W2912534619 hasConcept C2778271984 @default.
• W2912534619 hasConcept C3018791406 @default.
• W2912534619 hasConcept C54355233 @default.
• W2912534619 hasConcept C6997183 @default.
• W2912534619 hasConcept C71924100 @default.
• W2912534619 hasConcept C86803240 @default.
• W2912534619 hasConcept C95444343 @default.
• W2912534619 hasConceptScore W2912534619C102230213 @default.
• W2912534619 hasConceptScore W2912534619C104317684 @default.
• W2912534619 hasConceptScore W2912534619C126322002 @default.
• W2912534619 hasConceptScore W2912534619C134018914 @default.
• W2912534619 hasConceptScore W2912534619C141035611 @default.
• W2912534619 hasConceptScore W2912534619C150194340 @default.
• W2912534619 hasConceptScore W2912534619C162317418 @default.
• W2912534619 hasConceptScore W2912534619C167414201 @default.
• W2912534619 hasConceptScore W2912534619C205875245 @default.
• W2912534619 hasConceptScore W2912534619C2778069365 @default.
• W2912534619 hasConceptScore W2912534619C2778271984 @default.
• W2912534619 hasConceptScore W2912534619C3018791406 @default.
• W2912534619 hasConceptScore W2912534619C54355233 @default.
• W2912534619 hasConceptScore W2912534619C6997183 @default.
• W2912534619 hasConceptScore W2912534619C71924100 @default.
• W2912534619 hasConceptScore W2912534619C86803240 @default.
• W2912534619 hasConceptScore W2912534619C95444343 @default.
• W2912534619 hasIssue "suppl_1" @default.
• W2912534619 hasLocation W29125346191 @default.
• W2912534619 hasOpenAccess W2912534619 @default.
• W2912534619 hasPrimaryLocation W29125346191 @default.
• W2912534619 hasRelatedWork W1979363352 @default.
• W2912534619 hasRelatedWork W2018690794 @default.
• W2912534619 hasRelatedWork W2024618244 @default.
• W2912534619 hasRelatedWork W2039226971 @default.
• W2912534619 hasRelatedWork W2055571680 @default.
• W2912534619 hasRelatedWork W2104791454 @default.
• W2912534619 hasRelatedWork W2122395778 @default.
• W2912534619 hasRelatedWork W2474907716 @default.
• W2912534619 hasRelatedWork W2764849705 @default.
• W2912534619 hasRelatedWork W4248381333 @default.
• W2912534619 hasVolume "121" @default.
• W2912534619 isParatext "false" @default.
• W2912534619 isRetracted "false" @default.
• W2912534619 magId "2912534619" @default.
• W2912534619 workType "article" @default.