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- W2912543621 startingPage "426" @default.
- W2912543621 abstract "Recent advances in our understanding of the contribution of thrombin generation to arterial thrombosis and the role of platelets in venous thrombosis have prompted new treatment paradigms. Nonetheless, bleeding remains the major side effect of such treatments spurring the quest for new antithrombotic regimens with better benefit-risk profiles and for safer anticoagulants for existing and new indications. The aims of this article are to review the results of recent trials aimed at enhancing the benefit-risk profile of antithrombotic therapy and explain how these findings are changing our approach to the management of arterial and venous thrombosis. Focusing on these 2 aspects of thrombosis management, this article discusses 4 advances: (1) the observation that in some indications, lowering the dose of some direct oral anticoagulants reduces the risk of bleeding without compromising efficacy, (2) the recognition that aspirin is not only effective for secondary prevention of atherothrombosis but also for prevention of venous thromboembolism, (3) the finding that dual pathway inhibition with the combination of low-dose rivaroxaban to attenuate thrombin generation plus aspirin to reduce thromboxane A2-mediated platelet activation is superior to aspirin or rivaroxaban alone for prevention of atherothrombosis in patients with coronary or peripheral artery disease, and (4) the development of inhibitors of factor XI or XII as potentially safer anticoagulants." @default.
- W2912543621 created "2019-02-21" @default.
- W2912543621 creator A5061132830 @default.
- W2912543621 creator A5082464840 @default.
- W2912543621 date "2019-02-01" @default.
- W2912543621 modified "2023-10-16" @default.
- W2912543621 title "Antithrombotic Agents" @default.
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- W2912543621 doi "https://doi.org/10.1161/circresaha.118.313155" @default.
- W2912543621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30702990" @default.
- W2912543621 hasPublicationYear "2019" @default.
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