Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912550025> ?p ?o ?g. }
- W2912550025 endingPage "11" @default.
- W2912550025 startingPage "1" @default.
- W2912550025 abstract "Several studies suggest that there is a biologically plausible connection between rheumatoid arthritis (RA) and periodontal diseases (PD). Both disorders are characterized as multifactorial diseases potentially sharing common risk factors. Based on the inflammatory nature of RA and PD, the impact of genetic variations of genes of the immune system on both diseases was studied in this study.We conducted a case-control study (n = 201) comparing 101 RA patients suffering from periodontal disease of different severities (no/mild PD vs. severe PD) with 100 systemically healthy controls without RA and severe PD. The genotype, allele, and haplotype distributions of 22 SNPs of 13 pro- and anti-inflammatory cytokines were assessed applying sequence-specific PCR.Evaluating the impact of cytokine SNPs in RA, we identified the G allele of rs1801275 in IL4Rα (p = 0.043) and the G allele of rs361525 in TNFα (p = 0.005) as disease-associated risk factors in bivariate analyses. In multivariate analyses, these significant associations could not be proven. The A allele of rs2430561 in IFNγ was indicative for severe periodontitis among the patients with rheumatoid arthritis (p = 0.039). Investigating the impact of rs2430561 in IFNγ on comorbidity using binary logistic regression analyses, the A allele was confirmed as an independent risk factor for severe periodontal disease and RA (p = 0.024).These results emphasize the association of genetic variations in proinflammatory cytokines (TNFα and IFNγ) and cytokine receptor (IL4Rα) and RA and periodontal diseases. In multivariate analyses, the A allele of IFNγ was proven to be a significant marker of RA and PD comorbidities. The study broadens the knowledge about disease-specific differences in genetic composition and provides an improved understanding of a possible association of both diseases." @default.
- W2912550025 created "2019-02-21" @default.
- W2912550025 creator A5001195965 @default.
- W2912550025 creator A5022512937 @default.
- W2912550025 creator A5056330057 @default.
- W2912550025 creator A5067692863 @default.
- W2912550025 creator A5083346400 @default.
- W2912550025 date "2019-02-12" @default.
- W2912550025 modified "2023-10-14" @default.
- W2912550025 title "Are There Any Common Genetic Risk Markers for Rheumatoid Arthritis and Periodontal Diseases? A Case-Control Study" @default.
- W2912550025 cites W1552020203 @default.
- W2912550025 cites W1800567007 @default.
- W2912550025 cites W1838850534 @default.
- W2912550025 cites W1840060372 @default.
- W2912550025 cites W1903538181 @default.
- W2912550025 cites W1933247184 @default.
- W2912550025 cites W1943338444 @default.
- W2912550025 cites W1959064313 @default.
- W2912550025 cites W196399099 @default.
- W2912550025 cites W1966624028 @default.
- W2912550025 cites W1968142189 @default.
- W2912550025 cites W1969078493 @default.
- W2912550025 cites W1969291889 @default.
- W2912550025 cites W1976796305 @default.
- W2912550025 cites W1983986500 @default.
- W2912550025 cites W1986488805 @default.
- W2912550025 cites W1992767581 @default.
- W2912550025 cites W1993619623 @default.
- W2912550025 cites W2002133510 @default.
- W2912550025 cites W2007106048 @default.
- W2912550025 cites W2013829757 @default.
- W2912550025 cites W2022126078 @default.
- W2912550025 cites W2022488018 @default.
- W2912550025 cites W2029315103 @default.
- W2912550025 cites W2033555369 @default.
- W2912550025 cites W2037572666 @default.
- W2912550025 cites W2043390209 @default.
- W2912550025 cites W2043842930 @default.
- W2912550025 cites W2047885446 @default.
- W2912550025 cites W2062732772 @default.
- W2912550025 cites W2064990609 @default.
- W2912550025 cites W2073552542 @default.
- W2912550025 cites W2079782844 @default.
- W2912550025 cites W2082573389 @default.
- W2912550025 cites W2088341649 @default.
- W2912550025 cites W2090329301 @default.
- W2912550025 cites W2096951937 @default.
- W2912550025 cites W2097013260 @default.
- W2912550025 cites W2101287311 @default.
- W2912550025 cites W2104616747 @default.
- W2912550025 cites W2108165667 @default.
- W2912550025 cites W2110013055 @default.
- W2912550025 cites W2110043964 @default.
- W2912550025 cites W2112947049 @default.
- W2912550025 cites W2116227354 @default.
- W2912550025 cites W2118819906 @default.
- W2912550025 cites W2118945216 @default.
- W2912550025 cites W2124074233 @default.
- W2912550025 cites W2124172780 @default.
- W2912550025 cites W2128952811 @default.
- W2912550025 cites W2130195917 @default.
- W2912550025 cites W2131131455 @default.
- W2912550025 cites W2133402546 @default.
- W2912550025 cites W2140313407 @default.
- W2912550025 cites W2142251304 @default.
- W2912550025 cites W2148830915 @default.
- W2912550025 cites W2150625070 @default.
- W2912550025 cites W2155356768 @default.
- W2912550025 cites W2155616821 @default.
- W2912550025 cites W2163341572 @default.
- W2912550025 cites W2167095762 @default.
- W2912550025 cites W2168670867 @default.
- W2912550025 cites W2181009879 @default.
- W2912550025 cites W2190746467 @default.
- W2912550025 cites W2218778538 @default.
- W2912550025 cites W2273452210 @default.
- W2912550025 cites W2294284221 @default.
- W2912550025 cites W2316294584 @default.
- W2912550025 cites W2377947018 @default.
- W2912550025 cites W2414338921 @default.
- W2912550025 cites W2513738779 @default.
- W2912550025 cites W2549064117 @default.
- W2912550025 cites W2560542743 @default.
- W2912550025 cites W2567870642 @default.
- W2912550025 cites W2607941154 @default.
- W2912550025 cites W2608813759 @default.
- W2912550025 cites W2627037103 @default.
- W2912550025 cites W2633532022 @default.
- W2912550025 cites W2757161682 @default.
- W2912550025 cites W2790916758 @default.
- W2912550025 cites W2794853230 @default.
- W2912550025 cites W2804769149 @default.
- W2912550025 cites W2810657527 @default.
- W2912550025 cites W2899434168 @default.
- W2912550025 cites W34403498 @default.
- W2912550025 cites W4210968471 @default.
- W2912550025 cites W63909035 @default.
- W2912550025 cites W787345825 @default.