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• W2912551171 endingPage "111" @default.
• W2912551171 startingPage "102" @default.
• W2912551171 abstract "In recent times, there has been a growing tendency to treat advanced gynaecological malignancies with neoadjuvant chemotherapy (NACT), with the goal of reducing tumour volume and enhancing operability resulting in optimal cytoreduction. This approach is used in particular for patients with advanced high-grade serous carcinoma of the ovary, fallopian tube or peritoneum. Pathology plays a crucial role in the management of these patients, both before and after NACT. Prior to initiation of NACT, a biopsy should be performed, usually of the omental cake, to confirm that a malignancy is present, to identify the site of origin of the tumour and to type and grade the tumour. Histopathologists must be aware of the resultant morphological effects of NACT when examining specimens following interval cytoreduction surgery. Tumour typing and grading, and even the identification of residual neoplasia, are particular challenges. Immunohistochemistry, when used judiciously, can be a useful adjunct in certain scenarios. A pathological assessment of the response to chemotherapy, and the pathological stage should be provided in the pathology report, as these may inform prognosis and subsequent management. We present a comprehensive overview of the relevant clinical and pathological aspects pertaining to NACT for gynaecological malignancies for the practicing surgical pathologist." @default.
• W2912551171 created "2019-02-21" @default.
• W2912551171 creator A5005275599 @default.
• W2912551171 creator A5005785391 @default.
• W2912551171 creator A5014266123 @default.
• W2912551171 creator A5047507754 @default.
• W2912551171 creator A5069049987 @default.
• W2912551171 date "2019-01-22" @default.
• W2912551171 modified "2023-09-27" @default.
• W2912551171 title "Neoadjuvant therapy in gynaecological malignancies: What pathologists need to know" @default.
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• W2912551171 doi "https://doi.org/10.1136/jclinpath-2018-205634" @default.

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