FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912551797> ?p ?o ?g. }

• W2912551797 endingPage "402" @default.
• W2912551797 startingPage "383" @default.
• W2912551797 abstract "Protein‐losing enteropathy, or PLE, is not a disease but a syndrome that develops in numerous disease states of differing etiologies and often involving the lymphatic system, such as lymphangiectasia and lymphangitis in dogs. The pathophysiology of lymphatic disease is incompletely understood, and the disease is challenging to manage. Understanding of PLE mechanisms requires knowledge of lymphatic system structure and function, which are reviewed here. The mechanisms of enteric protein loss in PLE are identical in dogs and people, irrespective of the underlying cause. In people, PLE is usually associated with primary intestinal lymphangiectasia, suspected to arise from genetic susceptibility, or “idiopathic” lymphatic vascular obstruction. In dogs, PLE is most often a feature of inflammatory bowel disease (IBD), and less frequently intestinal lymphangiectasia, although it is not proven which process is the true driving defect. In cats, PLE is relatively rare. Review of the veterinary literature (1977‐2018) reveals that PLE was life‐ending in 54.2% of dogs compared to published disease‐associated deaths in IBD of <20%, implying that PLE is not merely a continuum of IBD spectrum pathophysiology. In people, diet is the cornerstone of management, whereas dogs are often treated with immunosuppression for causes of PLE including lymphangiectasia, lymphangitis, and crypt disease. Currently, however, there is no scientific, extrapolated, or evidence‐based support for an autoimmune or immune‐mediated mechanism. Moreover, people with PLE have disease‐associated loss of immune function, including lymphopenia, severe CD4+ T‐cell depletion, and negative vaccinal titers. Comparison of PLE in people and dogs is undertaken here, and theories in treatment of PLE are presented." @default.
• W2912551797 created "2019-02-21" @default.
• W2912551797 creator A5003522607 @default.
• W2912551797 creator A5066553005 @default.
• W2912551797 date "2019-02-14" @default.
• W2912551797 modified "2023-10-14" @default.
• W2912551797 title "Comparative pathophysiology and management of protein‐losing enteropathy" @default.
• W2912551797 cites W135590438 @default.
• W2912551797 cites W1490398479 @default.
• W2912551797 cites W1531112711 @default.
• W2912551797 cites W1531264887 @default.
• W2912551797 cites W1561393678 @default.
• W2912551797 cites W1601356132 @default.
• W2912551797 cites W1716171481 @default.
• W2912551797 cites W177681128 @default.
• W2912551797 cites W1900765734 @default.
• W2912551797 cites W1909714874 @default.
• W2912551797 cites W1963936455 @default.
• W2912551797 cites W1965395539 @default.
• W2912551797 cites W1966481846 @default.
• W2912551797 cites W1968477293 @default.
• W2912551797 cites W1969868235 @default.
• W2912551797 cites W1974327984 @default.
• W2912551797 cites W1976968895 @default.
• W2912551797 cites W1979268036 @default.
• W2912551797 cites W1981195473 @default.
• W2912551797 cites W1985616458 @default.
• W2912551797 cites W1986581917 @default.
• W2912551797 cites W1988338839 @default.
• W2912551797 cites W1991331872 @default.
• W2912551797 cites W1991346408 @default.
• W2912551797 cites W1991994592 @default.
• W2912551797 cites W1993374058 @default.
• W2912551797 cites W1995225946 @default.
• W2912551797 cites W1995560372 @default.
• W2912551797 cites W1998853404 @default.
• W2912551797 cites W2001084239 @default.
• W2912551797 cites W2009095143 @default.
• W2912551797 cites W2009292320 @default.
• W2912551797 cites W2016219300 @default.
• W2912551797 cites W2016748542 @default.
• W2912551797 cites W2017144627 @default.
• W2912551797 cites W2018938367 @default.
• W2912551797 cites W2020637525 @default.
• W2912551797 cites W2021197424 @default.
• W2912551797 cites W2022755558 @default.
• W2912551797 cites W2022840456 @default.
• W2912551797 cites W2024591497 @default.
• W2912551797 cites W2027590052 @default.
• W2912551797 cites W2029089542 @default.
• W2912551797 cites W2032836163 @default.
• W2912551797 cites W2033811086 @default.
• W2912551797 cites W2037026348 @default.
• W2912551797 cites W2037380046 @default.
• W2912551797 cites W2038803910 @default.
• W2912551797 cites W2040633500 @default.
• W2912551797 cites W2042613715 @default.
• W2912551797 cites W2046606347 @default.
• W2912551797 cites W2047417119 @default.
• W2912551797 cites W2048076060 @default.
• W2912551797 cites W2050093406 @default.
• W2912551797 cites W2052730385 @default.
• W2912551797 cites W2056585868 @default.
• W2912551797 cites W2056594533 @default.
• W2912551797 cites W2058502124 @default.
• W2912551797 cites W2059931557 @default.
• W2912551797 cites W2061904336 @default.
• W2912551797 cites W2062483260 @default.
• W2912551797 cites W2065597851 @default.
• W2912551797 cites W2067150213 @default.
• W2912551797 cites W2068734467 @default.
• W2912551797 cites W2071955092 @default.
• W2912551797 cites W2077179773 @default.
• W2912551797 cites W2078511476 @default.
• W2912551797 cites W2082239266 @default.
• W2912551797 cites W2083050654 @default.
• W2912551797 cites W2083847996 @default.
• W2912551797 cites W2087547551 @default.
• W2912551797 cites W2087917149 @default.
• W2912551797 cites W2088194700 @default.
• W2912551797 cites W2088234393 @default.
• W2912551797 cites W2091528585 @default.
• W2912551797 cites W2092799324 @default.
• W2912551797 cites W2093248557 @default.
• W2912551797 cites W2096156778 @default.
• W2912551797 cites W2097072956 @default.
• W2912551797 cites W2100726669 @default.
• W2912551797 cites W2103036805 @default.
• W2912551797 cites W2111178226 @default.
• W2912551797 cites W2112144039 @default.
• W2912551797 cites W2112225762 @default.
• W2912551797 cites W2113265524 @default.
• W2912551797 cites W2116146278 @default.
• W2912551797 cites W2119007163 @default.
• W2912551797 cites W2123241393 @default.
• W2912551797 cites W2124975462 @default.
• W2912551797 cites W2126263193 @default.
• W2912551797 cites W2134643141 @default.

• next