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- W2912557152 abstract "Multivesicular bodies (MVBs) are critical intermediates in the trafficking of ubiquitinated endocytosed surface proteins to the lysosome/vacuole for destruction. Recognizing and packaging ubiquitin modified cargoes to the MVB pathway require ESCRT (Endosomal sorting complexes required for transport) machinery, which consists of four core subcomplexes, ESCRT-0, ESCRT-I, ESCRT-II and ESCRT-III. Fusarium graminearum is an important plant pathogen that causes head blight of major cereal crops. Our previous results showed that ESCRT-0 is essential for fungal development and pathogenicity in Fusarium graminearum. We then, in this study, systemically studied the protein-protein interactions within F. graminearum ESCRT-I, -II or -III complex, as well as between ESCRT-0 and ESCRT-I, ESCRT-I and ESCRT-II, and ESCRT-II and ESCRT-III complexes and found that loss of any ESCRT component resulted in abnormal function in endocytosis. In addition, ESCRT deletion mutants displayed severe defects in growth, deoxynivalenol (DON) production, virulence, sexual and asexual reproduction. Importantly genetic complementation with corresponding ESCRT genes fully rescued all these defective phenotypes, indicating the essential role of ESCRT machinery in fungal development and plant infection in F. graminearum. Taken together, the protein-protein interactome and biological functions of the ESCRT machinery is first profoundly characterized in F. graminearum, providing a foundation for further exploration of ESCRT machinery in filamentous fungi." @default.
- W2912557152 created "2019-02-21" @default.
- W2912557152 creator A5011362260 @default.
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- W2912557152 date "2019-02-12" @default.
- W2912557152 modified "2023-10-16" @default.
- W2912557152 title "Component Interaction of ESCRT Complexes Is Essential for Endocytosis-Dependent Growth, Reproduction, DON Production and Full Virulence in Fusarium graminearum" @default.
- W2912557152 cites W1499176799 @default.
- W2912557152 cites W1568990285 @default.
- W2912557152 cites W1767202943 @default.
- W2912557152 cites W1857570710 @default.
- W2912557152 cites W1898108646 @default.
- W2912557152 cites W1970518843 @default.
- W2912557152 cites W1971948144 @default.
- W2912557152 cites W1973214920 @default.
- W2912557152 cites W1973572007 @default.
- W2912557152 cites W1975468372 @default.
- W2912557152 cites W1978141733 @default.
- W2912557152 cites W1981515958 @default.
- W2912557152 cites W1982606786 @default.
- W2912557152 cites W1985001103 @default.
- W2912557152 cites W1986105167 @default.
- W2912557152 cites W1987984945 @default.
- W2912557152 cites W1991668347 @default.
- W2912557152 cites W1994569042 @default.
- W2912557152 cites W1997962605 @default.
- W2912557152 cites W1998079639 @default.
- W2912557152 cites W2003979167 @default.
- W2912557152 cites W2010767491 @default.
- W2912557152 cites W2010985015 @default.
- W2912557152 cites W2014047335 @default.
- W2912557152 cites W2014832341 @default.
- W2912557152 cites W2019215631 @default.
- W2912557152 cites W2023804649 @default.
- W2912557152 cites W2024549899 @default.
- W2912557152 cites W2026273381 @default.
- W2912557152 cites W2027286196 @default.
- W2912557152 cites W2027648033 @default.
- W2912557152 cites W2034183549 @default.
- W2912557152 cites W2034894366 @default.
- W2912557152 cites W2035178600 @default.
- W2912557152 cites W2037087465 @default.
- W2912557152 cites W2039695824 @default.
- W2912557152 cites W2041780232 @default.
- W2912557152 cites W2042158953 @default.
- W2912557152 cites W2043565517 @default.
- W2912557152 cites W2043591953 @default.
- W2912557152 cites W2047791387 @default.
- W2912557152 cites W2047792276 @default.
- W2912557152 cites W2049018382 @default.
- W2912557152 cites W2050544841 @default.
- W2912557152 cites W2056020649 @default.
- W2912557152 cites W2057118173 @default.
- W2912557152 cites W2070585766 @default.
- W2912557152 cites W2072425598 @default.
- W2912557152 cites W2075027086 @default.
- W2912557152 cites W2075265256 @default.
- W2912557152 cites W2076208523 @default.
- W2912557152 cites W2078374647 @default.
- W2912557152 cites W2079245186 @default.
- W2912557152 cites W2080526961 @default.
- W2912557152 cites W2083087230 @default.
- W2912557152 cites W2086088421 @default.
- W2912557152 cites W2089954309 @default.
- W2912557152 cites W2090932947 @default.
- W2912557152 cites W2095823649 @default.
- W2912557152 cites W2099674108 @default.
- W2912557152 cites W2103218284 @default.
- W2912557152 cites W2105211619 @default.
- W2912557152 cites W2105304590 @default.
- W2912557152 cites W2107277218 @default.
- W2912557152 cites W2112435922 @default.
- W2912557152 cites W2119351481 @default.
- W2912557152 cites W2121633863 @default.
- W2912557152 cites W2121715051 @default.
- W2912557152 cites W2121747690 @default.
- W2912557152 cites W2123460928 @default.
- W2912557152 cites W2124603595 @default.
- W2912557152 cites W2124621065 @default.
- W2912557152 cites W2131025644 @default.
- W2912557152 cites W2131662669 @default.
- W2912557152 cites W2133957638 @default.
- W2912557152 cites W2136605585 @default.
- W2912557152 cites W2137031771 @default.
- W2912557152 cites W2137506335 @default.
- W2912557152 cites W2140112779 @default.
- W2912557152 cites W2140253292 @default.
- W2912557152 cites W2142002552 @default.
- W2912557152 cites W2142485454 @default.
- W2912557152 cites W2145197740 @default.
- W2912557152 cites W2145625720 @default.
- W2912557152 cites W2146647617 @default.