Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912559738> ?p ?o ?g. }
- W2912559738 endingPage "121" @default.
- W2912559738 startingPage "115" @default.
- W2912559738 abstract "Purpose of review Intestinal-type adenocarcinoma (ITAC) is one of the most frequent sinonasal tumors, especially in European countries. The purpose of this article is to review the most recent literature, with special emphasis on biological and genetic profile and treatment guidelines. Recent findings Results on large series support transnasal endoscopic surgery as the technique of choice in the large majority of patients with ITAC. Adjuvant radiotherapy is recommended in advanced-stage and high-grade lesions. More robust data are required to confirm that early-stage, low-grade lesions can be treated with exclusive surgery. The efficacy of new chemotherapy and biotherapy regimens and the added value of heavy particle radiotherapy are currently under evaluation. With a 5-year overall survival ranging between 53 and 83%, which is mainly impacted by local recurrences, ITAC requires a more detailed understanding of its biology. Genetic and biological studies have identified alterations in the molecular pathways of EGFR, MET, and H-RAS which might be considered as potential targets for biotherapy. Summary Surgery still plays a key role in the treatment of ITAC, but multidisciplinary management is mandatory. Although further validation is needed, the role of nonsurgical treatment strategies is rising, in agreement with the progresses made in the biological profiling of the disease." @default.
- W2912559738 created "2019-02-21" @default.
- W2912559738 creator A5013780610 @default.
- W2912559738 creator A5018474702 @default.
- W2912559738 creator A5064060163 @default.
- W2912559738 date "2018-04-01" @default.
- W2912559738 modified "2023-10-18" @default.
- W2912559738 title "Intestinal-type adenocarcinoma of the sinonasal tract: an update" @default.
- W2912559738 cites W1504678485 @default.
- W2912559738 cites W1638528055 @default.
- W2912559738 cites W1680998545 @default.
- W2912559738 cites W1707497420 @default.
- W2912559738 cites W1790341906 @default.
- W2912559738 cites W1872870372 @default.
- W2912559738 cites W1969020720 @default.
- W2912559738 cites W1969624769 @default.
- W2912559738 cites W1982258982 @default.
- W2912559738 cites W1983245831 @default.
- W2912559738 cites W1988196699 @default.
- W2912559738 cites W1993631154 @default.
- W2912559738 cites W2002300001 @default.
- W2912559738 cites W2004546229 @default.
- W2912559738 cites W2008560474 @default.
- W2912559738 cites W2008897521 @default.
- W2912559738 cites W2028930414 @default.
- W2912559738 cites W2030076226 @default.
- W2912559738 cites W2035679542 @default.
- W2912559738 cites W2039554757 @default.
- W2912559738 cites W2039696847 @default.
- W2912559738 cites W2046482134 @default.
- W2912559738 cites W2048191333 @default.
- W2912559738 cites W2052352402 @default.
- W2912559738 cites W2055826713 @default.
- W2912559738 cites W2056614542 @default.
- W2912559738 cites W2057325015 @default.
- W2912559738 cites W2058478456 @default.
- W2912559738 cites W2058860653 @default.
- W2912559738 cites W2072960792 @default.
- W2912559738 cites W2076059862 @default.
- W2912559738 cites W2083866962 @default.
- W2912559738 cites W2090400923 @default.
- W2912559738 cites W2095647475 @default.
- W2912559738 cites W2102999878 @default.
- W2912559738 cites W2110876229 @default.
- W2912559738 cites W2119531917 @default.
- W2912559738 cites W2123863521 @default.
- W2912559738 cites W2128429516 @default.
- W2912559738 cites W2131370396 @default.
- W2912559738 cites W2144389533 @default.
- W2912559738 cites W2165499598 @default.
- W2912559738 cites W2166229764 @default.
- W2912559738 cites W2169715257 @default.
- W2912559738 cites W2176878852 @default.
- W2912559738 cites W2181068196 @default.
- W2912559738 cites W2184447124 @default.
- W2912559738 cites W2253888479 @default.
- W2912559738 cites W2257980055 @default.
- W2912559738 cites W2289403227 @default.
- W2912559738 cites W2302340670 @default.
- W2912559738 cites W2329190144 @default.
- W2912559738 cites W2409551698 @default.
- W2912559738 cites W2414115085 @default.
- W2912559738 cites W2436654341 @default.
- W2912559738 cites W2463310746 @default.
- W2912559738 cites W2485221435 @default.
- W2912559738 cites W2512124742 @default.
- W2912559738 cites W2550387450 @default.
- W2912559738 cites W2550574470 @default.
- W2912559738 cites W2571089854 @default.
- W2912559738 cites W2590986438 @default.
- W2912559738 cites W2598133152 @default.
- W2912559738 cites W2604906802 @default.
- W2912559738 cites W2766422892 @default.
- W2912559738 cites W2772454796 @default.
- W2912559738 cites W2782268236 @default.
- W2912559738 cites W4249973741 @default.
- W2912559738 cites W4256498027 @default.
- W2912559738 cites W65653778 @default.
- W2912559738 doi "https://doi.org/10.1097/moo.0000000000000445" @default.
- W2912559738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29389737" @default.
- W2912559738 hasPublicationYear "2018" @default.
- W2912559738 type Work @default.
- W2912559738 sameAs 2912559738 @default.
- W2912559738 citedByCount "26" @default.
- W2912559738 countsByYear W29125597382018 @default.
- W2912559738 countsByYear W29125597382019 @default.
- W2912559738 countsByYear W29125597382020 @default.
- W2912559738 countsByYear W29125597382021 @default.
- W2912559738 countsByYear W29125597382022 @default.
- W2912559738 countsByYear W29125597382023 @default.
- W2912559738 crossrefType "journal-article" @default.
- W2912559738 hasAuthorship W2912559738A5013780610 @default.
- W2912559738 hasAuthorship W2912559738A5018474702 @default.
- W2912559738 hasAuthorship W2912559738A5064060163 @default.
- W2912559738 hasBestOaLocation W29125597382 @default.
- W2912559738 hasConcept C121608353 @default.
- W2912559738 hasConcept C126322002 @default.
- W2912559738 hasConcept C141071460 @default.