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- W2912565055 abstract "Valvular interstitial cells (VICs) are the primary cell type residing within the heart valves. Under homeostatic conditions, these cells exhibit a quiescent, fibroblast-like phenotype. However, alterations in the microenvironment, including increased tissue stresses, can promote a transition to an activated, myofibroblast-like state. While this transition allows heart valves to maintain unidirectional blood flow during periods of growth and development, it is also a primary pathophysiological mechanism that leads to heart valve disease. Previous models have investigated the tissue and cellular biomechanics of VICs; however, a critical step linking cellular biomechanics to mechanotransduction is currently lacking. Therefore, a mathematical model of integrin-mediated mechanotransduction was developed to bridge this gap and provide key mechanistic insight to existing VIC biomechanics models. Initial steps toward a holistic multiscale model of VICs that incorporates both cellular mechanics and signal/mechanotransduction will be discussed." @default.
- W2912565055 created "2019-02-21" @default.
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- W2912565055 date "2019-02-01" @default.
- W2912565055 modified "2023-09-30" @default.
- W2912565055 title "Toward a Multiscale Model of Valvular Interstitial Cells: An Integrin-Mediated Mechanotransduction Module" @default.
- W2912565055 doi "https://doi.org/10.1016/j.bpj.2018.11.725" @default.
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