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- W2912580297 abstract "THE AIM: to assess the effect of ubiquitin-independent protein degradation on the development of protein metabolism disorders in patients with CKD who are treated with hemodialysis. PATIENTS AND METHODS : 80 patients with CKD treated with hemodialysis were examined. The study group included: 47 men and 33 women, whose average age was 51.7 ± 11.6 years, the duration of dialysis were 33.5 (0.5; 236) months. An anthropometric study, bioimpedancemetry, determination of muscle strength, biochemical blood analysis and an open ELISA for the presence of a 20S proteasome (20S-PSM) in the blood were carried out to all patients. RESULTS : When building regression analysis models, age, duration of dialysis, serum albumin, 20S proteasomes had a significant effect on muscle strength. There was no statistically significant correlation between the level of 20S-PSM and serum albumin and total protein as an independent result of proteasome protein degradation (p = 0.78; p = 0.80). CONCLUSION: The study demonstrated the relationship of the level of 20S proteasome with the features of dialysis treatment, the level of chronic inflammation. The change in body composition in the form of a compensatory increase in the absolute content of adipose tissue on the background of sarcopenia was not revealed according to the results of bio-impedance, which requires further study." @default.
- W2912580297 created "2019-02-21" @default.
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- W2912580297 date "2019-02-06" @default.
- W2912580297 modified "2023-09-26" @default.
- W2912580297 title "PROTEIN DEGRADATION BY THE UBIQUITIN-PROTEASOME PATHWAY IN PATIENTS WITH CHRONIC KIDNEY DISEASE STAGE 5D" @default.
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- W2912580297 doi "https://doi.org/10.24884/1561-6274-2019-23-1-73-78" @default.
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