Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912581010> ?p ?o ?g. }
- W2912581010 endingPage "1229" @default.
- W2912581010 startingPage "1222" @default.
- W2912581010 abstract "Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) has emerged as a label-free analytical tool for fast biomolecule profiling on tissue sections. Among various functional molecules, mapping neurotransmitters and related metabolites is of tremendous significance, as these compounds are critical to signaling in the central nervous system. Here, we demonstrated the use of both derivatization and reaction-free approaches that greatly reduced signal complexity and thus enabled complementary signaling molecule visualization on crab brain sections via MALDI-LTQ-Orbitrap XL platform. Pyrylium salt served as a primary amine derivatization reagent and produced prominent signal enhancement of multiple neurotransmitters, including dopamine, serotonin, γ-aminobutyric acid, and histamine that were not detected in underivatized tissues. Molecules with other functional groups, such as acetylcholine and phosphocholine, were directly imaged after matrix application. The identities of discovered neurotransmitters were verified by standards using LC-MS/MS. This study broadens our understanding of metabolic signaling in the crustacean nervous system and highlights potential of multifaceted MS techniques for unambiguous neurotransmitter characterization." @default.
- W2912581010 created "2019-02-21" @default.
- W2912581010 creator A5011159802 @default.
- W2912581010 creator A5014238331 @default.
- W2912581010 creator A5022993156 @default.
- W2912581010 creator A5028595660 @default.
- W2912581010 creator A5041058871 @default.
- W2912581010 creator A5041746783 @default.
- W2912581010 creator A5071820359 @default.
- W2912581010 creator A5085734930 @default.
- W2912581010 date "2019-02-05" @default.
- W2912581010 modified "2023-10-16" @default.
- W2912581010 title "Visualization and Identification of Neurotransmitters in Crustacean Brain via Multifaceted Mass Spectrometric Approaches" @default.
- W2912581010 cites W1829969087 @default.
- W2912581010 cites W1968390576 @default.
- W2912581010 cites W1989892701 @default.
- W2912581010 cites W1996265792 @default.
- W2912581010 cites W2001906042 @default.
- W2912581010 cites W2025023233 @default.
- W2912581010 cites W2025106467 @default.
- W2912581010 cites W2028911868 @default.
- W2912581010 cites W2033278243 @default.
- W2912581010 cites W2059725496 @default.
- W2912581010 cites W2063994009 @default.
- W2912581010 cites W2064469548 @default.
- W2912581010 cites W2069480516 @default.
- W2912581010 cites W2088727446 @default.
- W2912581010 cites W2090244687 @default.
- W2912581010 cites W2106989743 @default.
- W2912581010 cites W2108595785 @default.
- W2912581010 cites W2125394285 @default.
- W2912581010 cites W2126144602 @default.
- W2912581010 cites W2126838962 @default.
- W2912581010 cites W2130190326 @default.
- W2912581010 cites W2154463038 @default.
- W2912581010 cites W2157122930 @default.
- W2912581010 cites W2168748231 @default.
- W2912581010 cites W2315687228 @default.
- W2912581010 cites W2328610864 @default.
- W2912581010 cites W2345868453 @default.
- W2912581010 cites W2386102233 @default.
- W2912581010 cites W2624381181 @default.
- W2912581010 cites W2728162977 @default.
- W2912581010 cites W2760576070 @default.
- W2912581010 cites W2768118226 @default.
- W2912581010 cites W2785612404 @default.
- W2912581010 cites W2790600731 @default.
- W2912581010 cites W2888060232 @default.
- W2912581010 cites W2890025798 @default.
- W2912581010 cites W2897860205 @default.
- W2912581010 cites W2901165612 @default.
- W2912581010 cites W2905485852 @default.
- W2912581010 cites W4232098190 @default.
- W2912581010 doi "https://doi.org/10.1021/acschemneuro.8b00730" @default.
- W2912581010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6436947" @default.
- W2912581010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30721026" @default.
- W2912581010 hasPublicationYear "2019" @default.
- W2912581010 type Work @default.
- W2912581010 sameAs 2912581010 @default.
- W2912581010 citedByCount "34" @default.
- W2912581010 countsByYear W29125810102019 @default.
- W2912581010 countsByYear W29125810102020 @default.
- W2912581010 countsByYear W29125810102021 @default.
- W2912581010 countsByYear W29125810102022 @default.
- W2912581010 countsByYear W29125810102023 @default.
- W2912581010 crossrefType "journal-article" @default.
- W2912581010 hasAuthorship W2912581010A5011159802 @default.
- W2912581010 hasAuthorship W2912581010A5014238331 @default.
- W2912581010 hasAuthorship W2912581010A5022993156 @default.
- W2912581010 hasAuthorship W2912581010A5028595660 @default.
- W2912581010 hasAuthorship W2912581010A5041058871 @default.
- W2912581010 hasAuthorship W2912581010A5041746783 @default.
- W2912581010 hasAuthorship W2912581010A5071820359 @default.
- W2912581010 hasAuthorship W2912581010A5085734930 @default.
- W2912581010 hasBestOaLocation W29125810102 @default.
- W2912581010 hasConcept C162356407 @default.
- W2912581010 hasConcept C169760540 @default.
- W2912581010 hasConcept C170493617 @default.
- W2912581010 hasConcept C185592680 @default.
- W2912581010 hasConcept C22885893 @default.
- W2912581010 hasConcept C24066741 @default.
- W2912581010 hasConcept C2775910092 @default.
- W2912581010 hasConcept C2776219046 @default.
- W2912581010 hasConcept C2776923573 @default.
- W2912581010 hasConcept C43617362 @default.
- W2912581010 hasConcept C49853544 @default.
- W2912581010 hasConcept C513476851 @default.
- W2912581010 hasConcept C55493867 @default.
- W2912581010 hasConcept C70721500 @default.
- W2912581010 hasConcept C86803240 @default.
- W2912581010 hasConcept C98274493 @default.
- W2912581010 hasConceptScore W2912581010C162356407 @default.
- W2912581010 hasConceptScore W2912581010C169760540 @default.
- W2912581010 hasConceptScore W2912581010C170493617 @default.
- W2912581010 hasConceptScore W2912581010C185592680 @default.
- W2912581010 hasConceptScore W2912581010C22885893 @default.
- W2912581010 hasConceptScore W2912581010C24066741 @default.
- W2912581010 hasConceptScore W2912581010C2775910092 @default.