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- W2912581672 abstract "Large-scale transcriptome analyses have identified a variety of non-coding RNAs (ncRNAs) that are not translated into proteins. Many of them are in the nucleus, where they associate with chromatin and regulate its structure and function. Interphase chromosomes are intricately folded into multiple layers and composed of domains. Recent studies using Hi-C technologies have identified a mega-base self-associating chromatin domain: the topologically associating domain (TAD). The domain boundaries are demarcated with the chromatin regulatory proteins CTCF and cohesin, which are often bound to or recruited by ncRNAs. Some ncRNAs form RNA clouds in the nucleus and coordinate the transcription of multiple genes in a chromatin domain. In this review, we describe the emerging link between long ncRNAs and chromatin domains in the nucleus." @default.
- W2912581672 created "2019-02-21" @default.
- W2912581672 creator A5007855678 @default.
- W2912581672 creator A5013963270 @default.
- W2912581672 date "2019-06-01" @default.
- W2912581672 modified "2023-10-14" @default.
- W2912581672 title "Non-coding RNAs and chromatin domains" @default.
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- W2912581672 doi "https://doi.org/10.1016/j.ceb.2018.12.005" @default.
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