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- W2912582321 abstract "Age-related cognitive decline is a public health problem but highly diverse and difficult to predict. We captured nonoverlapping cognitive phenotypes in high-functioning adults and identified baseline factors differentiating trajectories. Three hundred fourteen functionally normal adults (M = 69 y) completed 2+ visits. Participants with sample-based longitudinal slopes in memory or processing speed less than -1 SD were classified as declining on that measure; 29 and 50 individuals had slopes less than -1 SD on processing speed or memory, respectively; 2.5% met criteria for both, who were excluded. At baseline, speed decliners demonstrated greater age, inflammation, and cognitive complaints compared with speed-stable adults; memory decliners were more likely to be male and had lower depressive symptoms, gray matter volumes, and white matter hyperintensities compared with memory-stable adults. Baseline speed, TNFα, and cognitive complaints accurately classified 96.3% of future speed decliners; baseline memory, sex, precuneal volume, and white matter hyperintensities accurately classified 88.5% of future memory decliners. There are discrete cognitive aging phenotypes reflecting nonoverlapping vulnerabilities in high-functioning adults. Early markers can predict cognition even within the normal spectrum and underscore therapeutic targets." @default.
- W2912582321 created "2019-02-21" @default.
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- W2912582321 date "2019-05-01" @default.
- W2912582321 modified "2023-10-15" @default.
- W2912582321 title "Cognitive aging is not created equally: differentiating unique cognitive phenotypes in “normal” adults" @default.
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- W2912582321 doi "https://doi.org/10.1016/j.neurobiolaging.2019.01.007" @default.
- W2912582321 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6486874" @default.
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