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• W2912582797 endingPage "946" @default.
• W2912582797 startingPage "935" @default.
• W2912582797 abstract "Abstract Acute lymphoblastic leukemia (ALL) comprises a heterogeneous group of hematologic malignancies, arising from diverse genetic alterations in the early lymphocyte development. T-cell subtype of ALL (T-ALL) accounts for about 15% and 25% of ALL in children and adults, respectively. Being less frequent among ALL subtypes, T-ALL represents a high-risk factor for poor prognosis due to its aggressiveness and resistance to common antileukemic drugs. Mitochondria were widely explored recently as a target for anticancer treatment because they are involved in a metabolic reprogramming of a cancer cell and play key roles in reactive oxygen species generation, Ca2+ signaling, and cell death induction. Accordingly, a new class of anticancer compounds named mitocans has been developed, which target mitochondria at distinct crucial points to promote their dysfunction and subsequent cell death. The present review analyses the role of mitochondria in malignant reprogramming and emerging therapeutic strategies targeting mitochondria as an “Achilles’ heel” in T-ALL, with an emphasis on BH3 mimetics, sequestering pro-survival BCL proteins and voltage-dependent anion channel (VDAC)1-directed drugs, which promote the suppression of aerobic glycolysis, VDAC1 closure, mitochondrial Ca2+ overload, stoppage of the oxidative phosphorylation, oxidative stress, and release of proapoptotic factors." @default.
• W2912582797 created "2019-02-21" @default.
• W2912582797 creator A5010311658 @default.
• W2912582797 creator A5033322392 @default.
• W2912582797 creator A5088801175 @default.
• W2912582797 date "2019-01-30" @default.
• W2912582797 modified "2023-09-27" @default.
• W2912582797 title "Mitochondria as emerging targets for therapies against T cell acute lymphoblastic leukemia" @default.
• W2912582797 cites W1480589927 @default.
• W2912582797 cites W1560222544 @default.
• W2912582797 cites W1920479129 @default.
• W2912582797 cites W1968092563 @default.
• W2912582797 cites W1970055550 @default.
• W2912582797 cites W1970990976 @default.
• W2912582797 cites W1972871470 @default.
• W2912582797 cites W1977838124 @default.
• W2912582797 cites W1979517153 @default.
• W2912582797 cites W1980804643 @default.
• W2912582797 cites W1987821813 @default.
• W2912582797 cites W1989026904 @default.
• W2912582797 cites W1989914782 @default.
• W2912582797 cites W1990983360 @default.
• W2912582797 cites W1992661831 @default.
• W2912582797 cites W1994740077 @default.
• W2912582797 cites W1994791278 @default.
• W2912582797 cites W1995421851 @default.
• W2912582797 cites W1995562352 @default.
• W2912582797 cites W1996789239 @default.
• W2912582797 cites W1998149716 @default.
• W2912582797 cites W1999882715 @default.
• W2912582797 cites W2000589976 @default.
• W2912582797 cites W2003959002 @default.
• W2912582797 cites W2005497718 @default.
• W2912582797 cites W2008085394 @default.
• W2912582797 cites W2013230402 @default.
• W2912582797 cites W2013624622 @default.
• W2912582797 cites W2017312650 @default.
• W2912582797 cites W2017333581 @default.
• W2912582797 cites W2024748688 @default.
• W2912582797 cites W2026450884 @default.
• W2912582797 cites W2028113479 @default.
• W2912582797 cites W2032787306 @default.
• W2912582797 cites W2032999577 @default.
• W2912582797 cites W2033643758 @default.
• W2912582797 cites W2034862605 @default.
• W2912582797 cites W2036881708 @default.
• W2912582797 cites W2047161358 @default.
• W2912582797 cites W2047586156 @default.
• W2912582797 cites W2048591984 @default.
• W2912582797 cites W2050253364 @default.
• W2912582797 cites W2050286706 @default.
• W2912582797 cites W2052846308 @default.
• W2912582797 cites W2053022803 @default.
• W2912582797 cites W2054691377 @default.
• W2912582797 cites W2054996277 @default.
• W2912582797 cites W2055063491 @default.
• W2912582797 cites W2056377340 @default.
• W2912582797 cites W2058305307 @default.
• W2912582797 cites W2066411725 @default.
• W2912582797 cites W2067169026 @default.
• W2912582797 cites W2067570858 @default.
• W2912582797 cites W2068154080 @default.
• W2912582797 cites W2068962767 @default.
• W2912582797 cites W2070962119 @default.
• W2912582797 cites W2075967786 @default.
• W2912582797 cites W2081812623 @default.
• W2912582797 cites W2084454660 @default.
• W2912582797 cites W2086350569 @default.
• W2912582797 cites W2093791243 @default.
• W2912582797 cites W2093917816 @default.
• W2912582797 cites W2095068941 @default.
• W2912582797 cites W2112020656 @default.
• W2912582797 cites W2124028938 @default.
• W2912582797 cites W2124529427 @default.
• W2912582797 cites W2124966133 @default.
• W2912582797 cites W2126701448 @default.
• W2912582797 cites W2128968369 @default.
• W2912582797 cites W2132847537 @default.
• W2912582797 cites W2133032371 @default.
• W2912582797 cites W2134727883 @default.
• W2912582797 cites W2135986226 @default.
• W2912582797 cites W2140258011 @default.
• W2912582797 cites W2141795335 @default.
• W2912582797 cites W2144277227 @default.
• W2912582797 cites W2144569256 @default.
• W2912582797 cites W2145540054 @default.
• W2912582797 cites W2145682243 @default.
• W2912582797 cites W2147373929 @default.
• W2912582797 cites W2150886441 @default.
• W2912582797 cites W2153408446 @default.
• W2912582797 cites W2155459097 @default.
• W2912582797 cites W2155830864 @default.
• W2912582797 cites W2157364449 @default.
• W2912582797 cites W2159447912 @default.
• W2912582797 cites W2161545183 @default.
• W2912582797 cites W2163572089 @default.
• W2912582797 cites W2168632005 @default.
• W2912582797 cites W2216772862 @default.

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