FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912582934> ?p ?o ?g. }

• W2912582934 endingPage "105" @default.
• W2912582934 startingPage "95" @default.
• W2912582934 abstract "Methionine (MET) restriction (MR) has been shown to arrest cancer growth and sensitizes tumors to chemotherapy. MR total parenteral nutrition (MR TPN) with a chemotherapy-containing amino acid solution (“AO-90”) (lacking both MET and L-cysteine[CYS]) showed synergistic effects with 5-fluorouracil (5-FU) in tumor-bearing rats and in a Phase I clinical trial with gastrointestinal tract cancers compared to 5-FU in a MET-containing TPN. All gastric cancer patients underwent gastrectomy. Resected tumors in the AO-90 group showed significant reduction of cancer histologically, while almost no effect was seen in the control group. A Phase II clinical trial of dietary MR combined with cystemustine treatment for melanoma or glioma was carried out. Twenty-two patients (20 with metastatic melanoma and 2 with recurrent gloma) received a median of four cycles of the combination of a 1-day MR diet with cystemustine (60 mg/m2) every 2 weeks. This combination was well tolerated (toxicity and nutritional status). The median disease-free survival was 1.8 months and the median survival was 4.6 months, with two long-duration stabilizations. MET depletion in plasma was 40%. In another study, eight patients with a variety of metastatic solid tumors were enrolled in a Phase I clinical trial of a commercially available MR medical food. Participants remained on the experimental diet for an average of 17.3 weeks. Plasma methionine levels fell from 21.6 to 9 μm within 2 weeks, a 58% decline. The only side effect was weight loss of approximately 0.5 kg per week. A feasibility study combining dietary MR with a FOLFOX regimen in patients with metastatic colorectal cancer was carried out. The plasma MET concentration was reduced by dietary MR by 58% on the first day of the MR diet. Among the four patients evaluable for response, three experienced a partial response and one patient had disease stabilization. The results of the above-described clinical trials indicate the clinical potential of MR." @default.
• W2912582934 created "2019-02-21" @default.
• W2912582934 creator A5040819666 @default.
• W2912582934 date "2019-01-01" @default.
• W2912582934 modified "2023-09-27" @default.
• W2912582934 title "Clinical Studies of Methionine-Restricted Diets for Cancer Patients" @default.
• W2912582934 cites W1844255926 @default.
• W2912582934 cites W1968663381 @default.
• W2912582934 cites W2017548604 @default.
• W2912582934 cites W2018213421 @default.
• W2912582934 cites W2018589424 @default.
• W2912582934 cites W2023441693 @default.
• W2912582934 cites W2034249385 @default.
• W2912582934 cites W2052998982 @default.
• W2912582934 cites W2055015121 @default.
• W2912582934 cites W2072099190 @default.
• W2912582934 cites W2075740270 @default.
• W2912582934 cites W2083754774 @default.
• W2912582934 cites W2159118239 @default.
• W2912582934 cites W2166889986 @default.
• W2912582934 cites W2172255822 @default.
• W2912582934 cites W2347178913 @default.
• W2912582934 cites W2593558254 @default.
• W2912582934 cites W2742450412 @default.
• W2912582934 cites W2769053959 @default.
• W2912582934 cites W2771508138 @default.
• W2912582934 cites W2772407589 @default.
• W2912582934 cites W2782140108 @default.
• W2912582934 cites W2791533954 @default.
• W2912582934 doi "https://doi.org/10.1007/978-1-4939-8796-2_9" @default.
• W2912582934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30725411" @default.
• W2912582934 hasPublicationYear "2019" @default.
• W2912582934 type Work @default.
• W2912582934 sameAs 2912582934 @default.
• W2912582934 citedByCount "17" @default.
• W2912582934 countsByYear W29125829342019 @default.
• W2912582934 countsByYear W29125829342020 @default.
• W2912582934 countsByYear W29125829342021 @default.
• W2912582934 countsByYear W29125829342022 @default.
• W2912582934 countsByYear W29125829342023 @default.
• W2912582934 crossrefType "book-chapter" @default.
• W2912582934 hasAuthorship W2912582934A5040819666 @default.
• W2912582934 hasConcept C121608353 @default.
• W2912582934 hasConcept C126322002 @default.
• W2912582934 hasConcept C141071460 @default.
• W2912582934 hasConcept C2776694085 @default.
• W2912582934 hasConcept C2777658100 @default.
• W2912582934 hasConcept C2778496288 @default.
• W2912582934 hasConcept C2780470880 @default.
• W2912582934 hasConcept C2780512811 @default.
• W2912582934 hasConcept C2780912031 @default.
• W2912582934 hasConcept C502942594 @default.
• W2912582934 hasConcept C511355011 @default.
• W2912582934 hasConcept C515207424 @default.
• W2912582934 hasConcept C526805850 @default.
• W2912582934 hasConcept C535046627 @default.
• W2912582934 hasConcept C542804219 @default.
• W2912582934 hasConcept C544821477 @default.
• W2912582934 hasConcept C55493867 @default.
• W2912582934 hasConcept C71924100 @default.
• W2912582934 hasConcept C86803240 @default.
• W2912582934 hasConcept C90924648 @default.
• W2912582934 hasConceptScore W2912582934C121608353 @default.
• W2912582934 hasConceptScore W2912582934C126322002 @default.
• W2912582934 hasConceptScore W2912582934C141071460 @default.
• W2912582934 hasConceptScore W2912582934C2776694085 @default.
• W2912582934 hasConceptScore W2912582934C2777658100 @default.
• W2912582934 hasConceptScore W2912582934C2778496288 @default.
• W2912582934 hasConceptScore W2912582934C2780470880 @default.
• W2912582934 hasConceptScore W2912582934C2780512811 @default.
• W2912582934 hasConceptScore W2912582934C2780912031 @default.
• W2912582934 hasConceptScore W2912582934C502942594 @default.
• W2912582934 hasConceptScore W2912582934C511355011 @default.
• W2912582934 hasConceptScore W2912582934C515207424 @default.
• W2912582934 hasConceptScore W2912582934C526805850 @default.
• W2912582934 hasConceptScore W2912582934C535046627 @default.
• W2912582934 hasConceptScore W2912582934C542804219 @default.
• W2912582934 hasConceptScore W2912582934C544821477 @default.
• W2912582934 hasConceptScore W2912582934C55493867 @default.
• W2912582934 hasConceptScore W2912582934C71924100 @default.
• W2912582934 hasConceptScore W2912582934C86803240 @default.
• W2912582934 hasConceptScore W2912582934C90924648 @default.
• W2912582934 hasLocation W29125829341 @default.
• W2912582934 hasLocation W29125829342 @default.
• W2912582934 hasOpenAccess W2912582934 @default.
• W2912582934 hasPrimaryLocation W29125829341 @default.
• W2912582934 hasRelatedWork W1619421778 @default.
• W2912582934 hasRelatedWork W1986497986 @default.
• W2912582934 hasRelatedWork W2026754264 @default.
• W2912582934 hasRelatedWork W2092221322 @default.
• W2912582934 hasRelatedWork W2166355973 @default.
• W2912582934 hasRelatedWork W2412448412 @default.
• W2912582934 hasRelatedWork W2415186990 @default.
• W2912582934 hasRelatedWork W3048581539 @default.
• W2912582934 hasRelatedWork W3130461542 @default.
• W2912582934 hasRelatedWork W191440478 @default.
• W2912582934 isParatext "false" @default.
• W2912582934 isRetracted "false" @default.

• next