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- W291258319 abstract "The affinity of different tissues for 75Se was studied after application of Na275SeO3in vitro and in vivo.In vitro the relative 75Se-incorporation in the tissues increases with increasing Na275SeO3 concentration. In tumor cells there was found an increase after the addition of glucose to the incubation medium.While in tumor cells the 75Se affinity is decreased by KCN or iodine-acetate only to 50 percent of the control values these compounds inhibit the 75Se-uptake in other tissue much stronger.Affinity studies with tumor bearing hamsters showed the following relation in the specific 75Se activity: kidney, liver, tumor, heart, muscle (28:25:7:5:1). This relation can be changed by addition of glucose. Corresponding to the results with the tumor bearing hamsters also in tumor bearing patients the 75Se activity decreases more rapidly in kidney and liver than in tumor and muscle.The results were discussed in connexion with the tumor szintigraphy with Na275SeO3." @default.
- W291258319 created "2016-06-24" @default.
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- W291258319 date "1971-06-01" @default.
- W291258319 modified "2023-09-26" @default.
- W291258319 title "Der einbau von 75Se nach applikation von radioaktivem natriumselenit in normalgewebe und in tumoren in-vitro und in-vivo" @default.
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- W291258319 doi "https://doi.org/10.1016/0020-708x(71)90063-9" @default.
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