FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912583429> ?p ?o ?g. }

• W2912583429 abstract "Background: Aluminum presents in many manufactured food, tooth paste and medicines. It is also addd to the drinking water for purification purposes. However, aluminum has been proved to have toxic effects on many organs of the human body. Some studies suggested that AlCl (aluminum chloride) have detrimental effects on the histology of the lungs of Sprague Dawley rats, which was eminent in the congested blood vessels and hemorrhage. On the other hand, Propolis is a resinous wax-like bee product collected by honey bees from plant exudates and also known as bee glue. In addition, Propolis has also been found to have powerful anti-inflammatory properties and can counteract the damaging effects of aluminium. Moreover, Propolis is the focus of a large number of research projects.Aim of work: Was to clarify the detailed histological changes in the lung resulting from aluminum toxicity and using propolis as a protective agent in albino rats.Material and Methods: Thirty adult Sprague Dawley male albino rats, 200- 250 gm body weight were used in the study. The animals were divided into three groups, ten rats each: Group I (control group): group Ia (5 rats) received distilled water and group Ib (5 rats) received propolis 50 mg/kg. B.W. once daily. Group II (AlCl3 group): received 475mg/kg B.W., of aluminum chloride once daily. Group III (protected group): received 475mg/kg B.W., of aluminum chloride and 50 mg/kg B.W. of Propolis once daily. All the doses were given via oral gavage. After eight weeks, all rats were anaesthetized by thiopental sodium and the thoracic cage was opened and the lungs were taken out. Specimens were processed for both light and transmission electron microscopic examination.Results: Examination of sections of lung tissue of group I (Ia and Ib) control groups showed almost the same findings, the lung had the appearance of fine lace because most of the tissue was composed of thin-walled alveoli. Examination of semithin sections revealed that the alveolar epithelium was formed of flattened squamous pneumocytes type I with its deeply stained nuclei and scanty cytoplasm. Pneumocytes type II were large irregular cuboidal cells with large rounded nuclei, prominent nucleoli and vacuolated cytoplasm. The ultrathin sections showed the pneumocyte type II with large heterochromatic nucleus and prominent nucleolus. The lungs of group II rats which received aluminum chloride showed diffuse affection. Alveoli were seen collapsed in many areas with thickening of the interalveolar septa. Congestion of the blood vessels together with extravasation of RBCs and heamosidrine granules were observed. Semithin sections showed cellular proliferation especially in pneumocytes type II was seen. Ultrathin sections revealed large areas of degeneration. Some nuclei appeared pykontic. The cytoplasm lost most of the organelles except few attenuated mitochondria. Examination of the Propolis protected group III showed that administration of propolis minimized the cellular proliferation caused by aluminium. In addition the obliteration of the alveolar lumen seemed less. Semithin sections of this group revealed some congestion of blood vessels and macrophages scattered in between the alveolar cells. Ultrathin sections showed pneumocytes type II with heterochromatic nucleus and prominent nucleoli and regular nuclear membrane and organelles rich cytoplasm. However, some residual degeneration could be detected in some pneumocytes.Conclusion: Based on the results of the present study, it can be concluded that aluminium chloride exposure had detrimental effects on the histology of the lungs of albino rats which could in turn negatively affect respiration. Therefore, caution should be taken in its usage. Administration of propolis combined with aluminium chloride can alleviate its harmful effects." @default.
• W2912583429 created "2019-02-21" @default.
• W2912583429 creator A5035721313 @default.
• W2912583429 creator A5053092428 @default.
• W2912583429 date "2017-07-01" @default.
• W2912583429 modified "2023-09-25" @default.
• W2912583429 title "A Study of the Effect of Aluminum Chloride on Pneumocyte Type II Cells of Albino Rats and Possible Protective Role of Propolis" @default.
• W2912583429 cites W1965983315 @default.
• W2912583429 cites W2002709837 @default.
• W2912583429 cites W2058435193 @default.
• W2912583429 cites W2062674765 @default.
• W2912583429 cites W2073582376 @default.
• W2912583429 cites W2076036306 @default.
• W2912583429 cites W2093421042 @default.
• W2912583429 cites W2095464585 @default.
• W2912583429 cites W2133760133 @default.
• W2912583429 cites W2181523551 @default.
• W2912583429 cites W3125561311 @default.
• W2912583429 doi "https://doi.org/10.21608/ejana.2018.16912" @default.
• W2912583429 hasPublicationYear "2017" @default.
• W2912583429 type Work @default.
• W2912583429 sameAs 2912583429 @default.
• W2912583429 citedByCount "0" @default.
• W2912583429 crossrefType "journal-article" @default.
• W2912583429 hasAuthorship W2912583429A5035721313 @default.
• W2912583429 hasAuthorship W2912583429A5053092428 @default.
• W2912583429 hasBestOaLocation W29125834291 @default.
• W2912583429 hasConcept C126322002 @default.
• W2912583429 hasConcept C185592680 @default.
• W2912583429 hasConcept C2779429693 @default.
• W2912583429 hasConcept C2780488879 @default.
• W2912583429 hasConcept C29730261 @default.
• W2912583429 hasConcept C31903555 @default.
• W2912583429 hasConcept C33070731 @default.
• W2912583429 hasConcept C43617362 @default.
• W2912583429 hasConcept C57742111 @default.
• W2912583429 hasConcept C71924100 @default.
• W2912583429 hasConcept C86803240 @default.
• W2912583429 hasConceptScore W2912583429C126322002 @default.
• W2912583429 hasConceptScore W2912583429C185592680 @default.
• W2912583429 hasConceptScore W2912583429C2779429693 @default.
• W2912583429 hasConceptScore W2912583429C2780488879 @default.
• W2912583429 hasConceptScore W2912583429C29730261 @default.
• W2912583429 hasConceptScore W2912583429C31903555 @default.
• W2912583429 hasConceptScore W2912583429C33070731 @default.
• W2912583429 hasConceptScore W2912583429C43617362 @default.
• W2912583429 hasConceptScore W2912583429C57742111 @default.
• W2912583429 hasConceptScore W2912583429C71924100 @default.
• W2912583429 hasConceptScore W2912583429C86803240 @default.
• W2912583429 hasLocation W29125834291 @default.
• W2912583429 hasOpenAccess W2912583429 @default.
• W2912583429 hasPrimaryLocation W29125834291 @default.
• W2912583429 hasRelatedWork W1861445424 @default.
• W2912583429 hasRelatedWork W1987523633 @default.
• W2912583429 hasRelatedWork W2260190953 @default.
• W2912583429 hasRelatedWork W2335080207 @default.
• W2912583429 hasRelatedWork W2462530877 @default.
• W2912583429 hasRelatedWork W2622204199 @default.
• W2912583429 hasRelatedWork W2622866936 @default.
• W2912583429 hasRelatedWork W2748871252 @default.
• W2912583429 hasRelatedWork W2801806635 @default.
• W2912583429 hasRelatedWork W2902217199 @default.
• W2912583429 hasRelatedWork W2914062695 @default.
• W2912583429 hasRelatedWork W2973162069 @default.
• W2912583429 hasRelatedWork W2991116547 @default.
• W2912583429 hasRelatedWork W2991160385 @default.
• W2912583429 hasRelatedWork W3006995293 @default.
• W2912583429 hasRelatedWork W3008801893 @default.
• W2912583429 hasRelatedWork W3091913266 @default.
• W2912583429 hasRelatedWork W3122462410 @default.
• W2912583429 hasRelatedWork W72730890 @default.
• W2912583429 hasRelatedWork W822691230 @default.
• W2912583429 isParatext "false" @default.
• W2912583429 isRetracted "false" @default.
• W2912583429 magId "2912583429" @default.
• W2912583429 workType "article" @default.