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• W2912583714 abstract "Human longevity involves genetic, nutritional, environmental and many other factors playing a key role in healthy aging. Previous studies have shown that mineral metabolism and homeostasis are associated with lifespan extension. However, the majority of them have focused on a limited number of elements and ignored the complex relationship between them. In this study, we carried out a network-based approach to investigate the urinary ionome of nonagenarians and centenarians (longevity group) when compared with their biologically unrelated and younger family members (control group) from a Han Chinese population. Several differentially changed elements were identified, almost all of which showed an elevated level in the longevity group. Correlation analysis of the ionome revealed significant element-element interactions in each group. We then divided each group into distinct subgroups according to age ranges, and built the elemental correlation network for each of them. Significant elemental correlations and correlation changes involving all examined elements were identified within or between different subgroups, implying a highly dynamic and complex crosstalk among the elements during human life. Finally, more similar elemental patterns were observed between extremely old and middle-aged people. Overall, our data reveal new relationship between urinary minerals and human longevity, which may extend our understanding of the mechanism of healthy aging." @default.
• W2912583714 created "2019-02-21" @default.
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• W2912583714 date "2019-05-01" @default.
• W2912583714 modified "2023-10-15" @default.
• W2912583714 title "Urinary ionomic analysis reveals new relationship between minerals and longevity in a Han Chinese population" @default.
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• W2912583714 doi "https://doi.org/10.1016/j.jtemb.2019.02.002" @default.
• W2912583714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30910209" @default.
• W2912583714 hasPublicationYear "2019" @default.
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