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- W2912584910 abstract "OBJECTIVE: To investigate the normal-appearing white matter (NAWM) structure of patients with multiple sclerosis (MS) and systemic lupus erythematosus (SLE) and healthy controls by using diffusion-tensor imaging (DTI) tract-based spatial statistic (TBSS). BACKGROUND: MS and SLE are central nervous system (CNS) diseases of autoimmune origin. Patients of both diseases present with neuropsychological impairment and formation of lesions and development of brain atrophy. The inherent differences in WM integrity of patients with these diseases compared to healthy controls are not understood. DESIGN/METHODS: The studied groups consisted of 30 relapsing-remitting MS patients (mean age of 43.8 ±8.4 and a mean disease duration of 12.1 ±7.9), 32 patients with SLE (mean age of 48.1 ±12.4 with a mean disease duration of 14.38 ±8.6) and 43 healthy controls (mean age of 44.7 ±9.8). DTI was performed on a 3T scanner in all patients and controls. The DTI images were post-processed using the FSL Software Package (Oxford, UK) and also Advanced Normalization Tools (ANTS) to correct for lesions. The images were then analyzed using a TBSS analysis. FSL9s randomize tool was used to perform permutation-based statistical inference. WM tract integrity was determined among the groups by comparing mean fractional anisotropy (FA). RESULTS: SLE patients and MS patients had decreased FA in subcortical areas compared to healthy controls (p CONCLUSIONS: This study shows that SLE and MS patients have microscopic damage to WM fiber structure compared with healthy controls. MS patients, however, have greater microscopic WM damage in the areas of high axonal traffic, like the thalamus and corpus callosum, compared to SLE patients. Supported by: National Institutes of Health grant NS049111 (J. Shucard, PI). Disclosure: Dr. Cesar has nothing to disclose. Dr. Shucard has nothing to disclose. Dr. Dwyer has nothing to disclose. Dr. Polak has nothing to disclose. Dr. Bergsland has nothing to disclose. Dr. Benedict has received personal compensation for activities with Actelion, Biogen Idec, Bayer, Novartis, MedImmune, EMD Serono and Teva Neuroscience. Dr. Benedict has received royalty payments from Psychological Assessment Resources. Dr. Benedict has received research support from Acorda Therapeutics and Biogen Idec. Dr. Shucard has nothing to disclose. Dr. Zivadinov has received personal compensation for activities with Teva Neuroscience, Biogen Idec, Serono, Inc., Genzyme Corporation, Sanofi-Aventis Pharmaceuticals, Inc., Bayer Pharmaceuticals, Questcor Pharmaceuticals and Novartis as a speaker and/or consultant. Dr. Zivadinov has received research support from Biogen Idec, Teva Neuroscience, Novartis, Genzyme Corporation, Sanofi-Aventis Pharmaceuticals, Inc., Bracco, Questcor Pharmaceuticals and Serono, Inc." @default.
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- W2912584910 date "2013-02-12" @default.
- W2912584910 modified "2023-09-26" @default.
- W2912584910 title "Comparing White Matter Tracts of Patients with Relapsing-Remitting Multiple Sclerosis, Systemic Lupus Erythematosus and Healthy Controls Using Tract-Based Spatial Statistics (TBSS) (P06.196)" @default.
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