Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912587193> ?p ?o ?g. }
- W2912587193 endingPage "2914" @default.
- W2912587193 startingPage "2908" @default.
- W2912587193 abstract "Abstract BACKGROUND Heterocyclic aromatic amines (HAAs) have been considered as carcinogenic and mutagenic chemicals generated during thermal processing of protein‐rich foods that can be inhibited by some flavonoids. Free radical scavenging is a major characteristic of flavonoids. RESULTS The half‐maximal inhibitory concentration (IC 50 ) values of nine flavonoids were determined by evaluating their capacity to inhibit 2‐amino‐3,8‐dimethylimidazo[4,5‐ f ]quinoxaline (MeIQx) and 2‐amino‐3,7,8‐trimethylimidazo[4,5‐ f ]quinoxaline (7,8‐DiMeIQx) formation in a model system. The results of the 2,2,6,6‐tetramethylpiperidine‐1‐oxyl (TEMPO) test validated that MeIQx and 7,8‐DiMeIQx formed via a free radical pathway. Electron spin resonance (ESR) spectroscopic analysis with spin trapping (α‐(4‐pyridyl N ‐oxide)‐ N ‐ tert ‐butylnitrone (POBN) spin adduct, a N = 15.2 G and a H = 2.7 G) revealed that an alkoxy radical was the generated intermediate. The scavenging capacities of the nine flavonoids on alkoxy radicals were then evaluated based on the ESR spectra of the POBN spin adducts. CONCLUSION The weak correlation between the alkoxy radical scavenging capacities and IC 50 of the flavonoids suggested that their inhibitory activity against MeIQx and 7,8‐DiMeIQx formation operates by a more complex mechanism than simply scavenging alkoxy radicals. © 2017 Society of Chemical Industry" @default.
- W2912587193 created "2019-02-21" @default.
- W2912587193 creator A5051434566 @default.
- W2912587193 creator A5059104456 @default.
- W2912587193 creator A5062121176 @default.
- W2912587193 creator A5066476250 @default.
- W2912587193 creator A5086664284 @default.
- W2912587193 date "2017-12-14" @default.
- W2912587193 modified "2023-09-30" @default.
- W2912587193 title "Inhibition effects of flavonoids on 2-amino-3,8-dimethylimidazo[4,5-<i>f</i> ]quinoxaline and 2-amino-3,7,8-trimethylimidazo[4,5-<i>f</i> ]quinoxaline formation and alkoxy radical scavenging capabilities of flavonoids in a model system" @default.
- W2912587193 cites W100989780 @default.
- W2912587193 cites W1966627797 @default.
- W2912587193 cites W1988710871 @default.
- W2912587193 cites W1989376033 @default.
- W2912587193 cites W1991021772 @default.
- W2912587193 cites W1999524549 @default.
- W2912587193 cites W2000733291 @default.
- W2912587193 cites W2002279346 @default.
- W2912587193 cites W2004721391 @default.
- W2912587193 cites W2005504875 @default.
- W2912587193 cites W2024921655 @default.
- W2912587193 cites W2026079714 @default.
- W2912587193 cites W2027278150 @default.
- W2912587193 cites W2036969998 @default.
- W2912587193 cites W2039023159 @default.
- W2912587193 cites W2040706396 @default.
- W2912587193 cites W2042374399 @default.
- W2912587193 cites W2050351065 @default.
- W2912587193 cites W2052381550 @default.
- W2912587193 cites W2052984003 @default.
- W2912587193 cites W2057537904 @default.
- W2912587193 cites W2068260320 @default.
- W2912587193 cites W2076515886 @default.
- W2912587193 cites W2079204640 @default.
- W2912587193 cites W2083803114 @default.
- W2912587193 cites W2094326888 @default.
- W2912587193 cites W2095080873 @default.
- W2912587193 cites W2286530528 @default.
- W2912587193 cites W2313174347 @default.
- W2912587193 cites W2333002048 @default.
- W2912587193 cites W2333129619 @default.
- W2912587193 cites W2460325623 @default.
- W2912587193 cites W2581251873 @default.
- W2912587193 cites W2615201473 @default.
- W2912587193 doi "https://doi.org/10.1002/jsfa.8785" @default.
- W2912587193 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29160907" @default.
- W2912587193 hasPublicationYear "2017" @default.
- W2912587193 type Work @default.
- W2912587193 sameAs 2912587193 @default.
- W2912587193 citedByCount "3" @default.
- W2912587193 countsByYear W29125871932020 @default.
- W2912587193 countsByYear W29125871932022 @default.
- W2912587193 crossrefType "journal-article" @default.
- W2912587193 hasAuthorship W2912587193A5051434566 @default.
- W2912587193 hasAuthorship W2912587193A5059104456 @default.
- W2912587193 hasAuthorship W2912587193A5062121176 @default.
- W2912587193 hasAuthorship W2912587193A5066476250 @default.
- W2912587193 hasAuthorship W2912587193A5086664284 @default.
- W2912587193 hasConcept C108204754 @default.
- W2912587193 hasConcept C139066938 @default.
- W2912587193 hasConcept C155647269 @default.
- W2912587193 hasConcept C178790620 @default.
- W2912587193 hasConcept C185592680 @default.
- W2912587193 hasConcept C2777807096 @default.
- W2912587193 hasConcept C2778004101 @default.
- W2912587193 hasConcept C2778815226 @default.
- W2912587193 hasConcept C2780263894 @default.
- W2912587193 hasConcept C2780362310 @default.
- W2912587193 hasConcept C71240020 @default.
- W2912587193 hasConcept C90150868 @default.
- W2912587193 hasConceptScore W2912587193C108204754 @default.
- W2912587193 hasConceptScore W2912587193C139066938 @default.
- W2912587193 hasConceptScore W2912587193C155647269 @default.
- W2912587193 hasConceptScore W2912587193C178790620 @default.
- W2912587193 hasConceptScore W2912587193C185592680 @default.
- W2912587193 hasConceptScore W2912587193C2777807096 @default.
- W2912587193 hasConceptScore W2912587193C2778004101 @default.
- W2912587193 hasConceptScore W2912587193C2778815226 @default.
- W2912587193 hasConceptScore W2912587193C2780263894 @default.
- W2912587193 hasConceptScore W2912587193C2780362310 @default.
- W2912587193 hasConceptScore W2912587193C71240020 @default.
- W2912587193 hasConceptScore W2912587193C90150868 @default.
- W2912587193 hasFunder F4320321001 @default.
- W2912587193 hasIssue "8" @default.
- W2912587193 hasLocation W29125871931 @default.
- W2912587193 hasLocation W29125871932 @default.
- W2912587193 hasOpenAccess W2912587193 @default.
- W2912587193 hasPrimaryLocation W29125871931 @default.
- W2912587193 hasRelatedWork W2007284540 @default.
- W2912587193 hasRelatedWork W2012589012 @default.
- W2912587193 hasRelatedWork W2031997549 @default.
- W2912587193 hasRelatedWork W2060734582 @default.
- W2912587193 hasRelatedWork W2085781744 @default.
- W2912587193 hasRelatedWork W2332442763 @default.
- W2912587193 hasRelatedWork W2367996327 @default.
- W2912587193 hasRelatedWork W2582746614 @default.
- W2912587193 hasRelatedWork W2912587193 @default.
- W2912587193 hasRelatedWork W3004955879 @default.