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• W2912588045 abstract "Starting from the recently launched FLT3/AXL multi-targeted inhibitor Gilteritinib (5), we conducted a side-chain ring closure medicinal chemistry approach leading to the identification of compound 15c as a highly potent AXL inhibitor in the biochemical and cellular anti-proliferative assays, with IC50 values of 1.2 and 0.3 nM, respectively. Compared with the reference compound 5, our new discovered AXL inhibitor 15c is more potent in both assays." @default.
• W2912588045 created "2019-02-21" @default.
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• W2912588045 date "2019-03-01" @default.
• W2912588045 modified "2023-09-27" @default.
• W2912588045 title "Discovery of a potent tyrosine kinase AXL inhibitor bearing the 3-((2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrazine core" @default.
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• W2912588045 doi "https://doi.org/10.1016/j.bmcl.2019.01.018" @default.
• W2912588045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30685094" @default.
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