FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912588451> ?p ?o ?g. }

• W2912588451 endingPage "856" @default.
• W2912588451 startingPage "844" @default.
• W2912588451 abstract "Multiple nodules in the lung are being diagnosed with an increasing frequency thanks to high-quality computed tomography imaging. In patients with lung cancer, this situation represents up to 10% of patients who have an operation. For clinical management, it is important to classify the disease as intrapulmonary metastasis or multiple primary lung carcinoma to define TNM classification and optimize therapeutic options. In the present study, we evaluated the respective and combined input of histological and molecular classification to propose a classification algorithm for multiple nodules.We studied consecutive patients undergoing an operation with curative intent for lung adenocarcinoma (N = 120) and harboring two tumors (N = 240). Histological diagnosis according to the WHO 2015 classification and molecular profiling using next-generation sequencing targeting 22 hotspot genes allowed classification of samples as multiple primary lung adenocarcinomas or as intrapulmonary metastasis.Next-generation sequencing identified molecular mutations in 91% of tumor pairs (109 of 120). Genomic and histological classification showed a fair agreement when the κ test was used (κ = 0.43). Discordant cases (30 of 109 [27%]) were reclassified by using a combined histomolecular algorithm. EGFR mutations (p = 0.03) and node involvement (p = 0.03) were significantly associated with intrapulmonary metastasis, whereas KRAS mutations (p = 0.00005) were significantly associated with multiple primary lung adenocarcinomas. EGFR mutations (p = 0.02) and node involvement (p = 0.004) were the only independent prognostic factors.We showed that combined histomolecular algorithm represents a relevant tool to classify multifocal lung cancers, which could guide adjuvant treatment decisions. Survival analysis underlined the good prognosis of EGFR-mutated adenocarcinoma in patients with intrapulmonary metastasis." @default.
• W2912588451 created "2019-02-21" @default.
• W2912588451 creator A5002499536 @default.
• W2912588451 creator A5012515730 @default.
• W2912588451 creator A5015888633 @default.
• W2912588451 creator A5018902791 @default.
• W2912588451 creator A5023361309 @default.
• W2912588451 creator A5039181362 @default.
• W2912588451 creator A5040162693 @default.
• W2912588451 creator A5053712155 @default.
• W2912588451 creator A5054966303 @default.
• W2912588451 creator A5057533024 @default.
• W2912588451 creator A5060265115 @default.
• W2912588451 creator A5065063253 @default.
• W2912588451 creator A5075646456 @default.
• W2912588451 creator A5078878520 @default.
• W2912588451 creator A5082993385 @default.
• W2912588451 creator A5085976480 @default.
• W2912588451 creator A5089818289 @default.
• W2912588451 date "2019-05-01" @default.
• W2912588451 modified "2023-10-18" @default.
• W2912588451 title "Proposal for a Combined Histomolecular Algorithm to Distinguish Multiple Primary Adenocarcinomas from Intrapulmonary Metastasis in Patients with Multiple Lung Tumors" @default.
• W2912588451 cites W1158033259 @default.
• W2912588451 cites W1847874933 @default.
• W2912588451 cites W1969531640 @default.
• W2912588451 cites W1973469228 @default.
• W2912588451 cites W1987357850 @default.
• W2912588451 cites W2008052505 @default.
• W2912588451 cites W2025568048 @default.
• W2912588451 cites W2032527506 @default.
• W2912588451 cites W2032995263 @default.
• W2912588451 cites W2034553744 @default.
• W2912588451 cites W2038268416 @default.
• W2912588451 cites W2053154970 @default.
• W2912588451 cites W2063759711 @default.
• W2912588451 cites W2066188259 @default.
• W2912588451 cites W2076348889 @default.
• W2912588451 cites W2080559054 @default.
• W2912588451 cites W2085712746 @default.
• W2912588451 cites W2088720324 @default.
• W2912588451 cites W2091919520 @default.
• W2912588451 cites W2092315165 @default.
• W2912588451 cites W2093274439 @default.
• W2912588451 cites W2093335481 @default.
• W2912588451 cites W2097935031 @default.
• W2912588451 cites W2106117130 @default.
• W2912588451 cites W2107017134 @default.
• W2912588451 cites W2108287705 @default.
• W2912588451 cites W2108371618 @default.
• W2912588451 cites W2109956432 @default.
• W2912588451 cites W2144601861 @default.
• W2912588451 cites W2147562944 @default.
• W2912588451 cites W2157369451 @default.
• W2912588451 cites W2161330635 @default.
• W2912588451 cites W2163149604 @default.
• W2912588451 cites W2169174541 @default.
• W2912588451 cites W2181276645 @default.
• W2912588451 cites W2251438188 @default.
• W2912588451 cites W2260064945 @default.
• W2912588451 cites W2288794117 @default.
• W2912588451 cites W2584148894 @default.
• W2912588451 cites W2585587591 @default.
• W2912588451 cites W2591772374 @default.
• W2912588451 cites W2702319702 @default.
• W2912588451 cites W2750741316 @default.
• W2912588451 cites W2796285985 @default.
• W2912588451 cites W2886492077 @default.
• W2912588451 cites W4251957537 @default.
• W2912588451 doi "https://doi.org/10.1016/j.jtho.2019.01.017" @default.
• W2912588451 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30721797" @default.
• W2912588451 hasPublicationYear "2019" @default.
• W2912588451 type Work @default.
• W2912588451 sameAs 2912588451 @default.
• W2912588451 citedByCount "45" @default.
• W2912588451 countsByYear W29125884512019 @default.
• W2912588451 countsByYear W29125884512020 @default.
• W2912588451 countsByYear W29125884512021 @default.
• W2912588451 countsByYear W29125884512022 @default.
• W2912588451 countsByYear W29125884512023 @default.
• W2912588451 crossrefType "journal-article" @default.
• W2912588451 hasAuthorship W2912588451A5002499536 @default.
• W2912588451 hasAuthorship W2912588451A5012515730 @default.
• W2912588451 hasAuthorship W2912588451A5015888633 @default.
• W2912588451 hasAuthorship W2912588451A5018902791 @default.
• W2912588451 hasAuthorship W2912588451A5023361309 @default.
• W2912588451 hasAuthorship W2912588451A5039181362 @default.
• W2912588451 hasAuthorship W2912588451A5040162693 @default.
• W2912588451 hasAuthorship W2912588451A5053712155 @default.
• W2912588451 hasAuthorship W2912588451A5054966303 @default.
• W2912588451 hasAuthorship W2912588451A5057533024 @default.
• W2912588451 hasAuthorship W2912588451A5060265115 @default.
• W2912588451 hasAuthorship W2912588451A5065063253 @default.
• W2912588451 hasAuthorship W2912588451A5075646456 @default.
• W2912588451 hasAuthorship W2912588451A5078878520 @default.
• W2912588451 hasAuthorship W2912588451A5082993385 @default.
• W2912588451 hasAuthorship W2912588451A5085976480 @default.
• W2912588451 hasAuthorship W2912588451A5089818289 @default.
• W2912588451 hasBestOaLocation W29125884511 @default.

• next