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• W2912588548 endingPage "629" @default.
• W2912588548 startingPage "620" @default.
• W2912588548 abstract "The small interfering RNAs (siRNA) or microRNAs (miRNA) incorporated into the RNA-induced silencing complex with the Argonaute (Ago) protein associates with target mRNAs through base-pairing, which leads to the cleavage or knockdown of the target mRNA. The seed region of the s(m)iRNA is crucial for target recognition. In this work, a molecular dynamic simulation was utilized to study the thermodynamics and kinetic properties of the third seed base binding to the target in the presence of the PIWI/MID domain of Ago. The results showed that in the presence of the PIWI/MID domain, the entropy and enthalpy changes for the association of the seed base with the target were smaller than those in the absence of protein. The binding affinity was increased due to the reduced entropy penalty, which resulted from the preorganization of the seed base into the A-helix form. In the presence of the protein, the association barrier resulting from the unfavorable entropy loss and the dissociation barrier coming from the destruction of hydrogen bonding and base-stacking interactions were lower than those in the absence of the protein. These results indicate that the seed region is crucial for fast recognition and association with the correct target." @default.
• W2912588548 created "2019-02-21" @default.
• W2912588548 creator A5011641116 @default.
• W2912588548 creator A5034686488 @default.
• W2912588548 creator A5042304241 @default.
• W2912588548 creator A5059431543 @default.
• W2912588548 creator A5065058975 @default.
• W2912588548 date "2019-02-15" @default.
• W2912588548 modified "2023-10-14" @default.
• W2912588548 title "Effects of the PIWI/MID domain of Argonaute protein on the association of miRNAi's seed base with the target" @default.
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• W2912588548 doi "https://doi.org/10.1261/rna.069328.118" @default.
• W2912588548 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6467011" @default.
• W2912588548 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30770397" @default.
• W2912588548 hasPublicationYear "2019" @default.
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