FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912588922> ?p ?o ?g. }

• W2912588922 endingPage "144" @default.
• W2912588922 startingPage "140" @default.
• W2912588922 abstract "The participation of endocannabinoids in central and peripheral antinociception induced by several compounds has been shown by our group. In this study, we investigated the effect of endocannabinoids on the central antinociception induced by ketamine. The nociceptive threshold for thermal stimulation was measured using the tail-flick test in Swiss mice. The drugs were administered intracerebroventricularly. Probabilities less than 5% (p < 0.05) were considered to be statistically significant (Two-way ANOVA/Bonferroni’s test). The CB1-selective cannabinoid receptor antagonist AM251 (2 and 4 μg) completely reversed the central antinociception induced by ketamine (4 μg) in a dose-dependent manner. In contrast, the CB2-selective cannabinoid receptor antagonist AM630 (2 and 4 μg) did not antagonize this effect. Additionally, the administration of the anandamide amidase inhibitor MAFP (0.2 μg) and anandamide uptake inhibitor VDM11 (4 μg) significantly enhanced the antinociception induced by a low dose of ketamine (2 μg). It was concluded that central antinociception induced by ketamine involves the activation of CB1 cannabinoid receptors. Mobilization of cannabinoids might be required for the activation of those receptors, since inhibitors of the endogenous cannabinoids potentiate the effect of Ketamine." @default.
• W2912588922 created "2019-02-21" @default.
• W2912588922 creator A5013897351 @default.
• W2912588922 creator A5014108092 @default.
• W2912588922 creator A5063539703 @default.
• W2912588922 date "2019-04-01" @default.
• W2912588922 modified "2023-09-25" @default.
• W2912588922 title "Ketamine induces central antinociception mediated by endogenous cannabinoids and activation of CB1 receptors" @default.
• W2912588922 cites W1487872499 @default.
• W2912588922 cites W1507804974 @default.
• W2912588922 cites W1575571855 @default.
• W2912588922 cites W1974140672 @default.
• W2912588922 cites W1982186440 @default.
• W2912588922 cites W1982751766 @default.
• W2912588922 cites W1987007555 @default.
• W2912588922 cites W1989163516 @default.
• W2912588922 cites W1995048478 @default.
• W2912588922 cites W1999822120 @default.
• W2912588922 cites W2002935274 @default.
• W2912588922 cites W2005828463 @default.
• W2912588922 cites W2017543199 @default.
• W2912588922 cites W2025055783 @default.
• W2912588922 cites W2039106853 @default.
• W2912588922 cites W2054998310 @default.
• W2912588922 cites W2061601726 @default.
• W2912588922 cites W2062413775 @default.
• W2912588922 cites W2065862147 @default.
• W2912588922 cites W2067909880 @default.
• W2912588922 cites W2070801110 @default.
• W2912588922 cites W2076069221 @default.
• W2912588922 cites W2082493917 @default.
• W2912588922 cites W2083371696 @default.
• W2912588922 cites W2084652074 @default.
• W2912588922 cites W2086238131 @default.
• W2912588922 cites W2088637181 @default.
• W2912588922 cites W2091435411 @default.
• W2912588922 cites W2092525482 @default.
• W2912588922 cites W2094763911 @default.
• W2912588922 cites W2112924959 @default.
• W2912588922 cites W2126766019 @default.
• W2912588922 cites W2128549678 @default.
• W2912588922 cites W2155840309 @default.
• W2912588922 cites W2158372492 @default.
• W2912588922 cites W2322548405 @default.
• W2912588922 cites W2557879850 @default.
• W2912588922 cites W2587258739 @default.
• W2912588922 cites W2626577148 @default.
• W2912588922 cites W2756243738 @default.
• W2912588922 cites W2763856387 @default.
• W2912588922 cites W2771559336 @default.
• W2912588922 cites W2111930261 @default.
• W2912588922 doi "https://doi.org/10.1016/j.neulet.2019.01.059" @default.
• W2912588922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30716423" @default.
• W2912588922 hasPublicationYear "2019" @default.
• W2912588922 type Work @default.
• W2912588922 sameAs 2912588922 @default.
• W2912588922 citedByCount "11" @default.
• W2912588922 countsByYear W29125889222019 @default.
• W2912588922 countsByYear W29125889222020 @default.
• W2912588922 countsByYear W29125889222022 @default.
• W2912588922 countsByYear W29125889222023 @default.
• W2912588922 crossrefType "journal-article" @default.
• W2912588922 hasAuthorship W2912588922A5013897351 @default.
• W2912588922 hasAuthorship W2912588922A5014108092 @default.
• W2912588922 hasAuthorship W2912588922A5063539703 @default.
• W2912588922 hasConcept C126322002 @default.
• W2912588922 hasConcept C148001335 @default.
• W2912588922 hasConcept C170493617 @default.
• W2912588922 hasConcept C185592680 @default.
• W2912588922 hasConcept C24998067 @default.
• W2912588922 hasConcept C2776158853 @default.
• W2912588922 hasConcept C2776885963 @default.
• W2912588922 hasConcept C2779783865 @default.
• W2912588922 hasConcept C2780433416 @default.
• W2912588922 hasConcept C2780795376 @default.
• W2912588922 hasConcept C2780871563 @default.
• W2912588922 hasConcept C42219234 @default.
• W2912588922 hasConcept C46721173 @default.
• W2912588922 hasConcept C55493867 @default.
• W2912588922 hasConcept C71924100 @default.
• W2912588922 hasConcept C93248783 @default.
• W2912588922 hasConcept C98274493 @default.
• W2912588922 hasConceptScore W2912588922C126322002 @default.
• W2912588922 hasConceptScore W2912588922C148001335 @default.
• W2912588922 hasConceptScore W2912588922C170493617 @default.
• W2912588922 hasConceptScore W2912588922C185592680 @default.
• W2912588922 hasConceptScore W2912588922C24998067 @default.
• W2912588922 hasConceptScore W2912588922C2776158853 @default.
• W2912588922 hasConceptScore W2912588922C2776885963 @default.
• W2912588922 hasConceptScore W2912588922C2779783865 @default.
• W2912588922 hasConceptScore W2912588922C2780433416 @default.
• W2912588922 hasConceptScore W2912588922C2780795376 @default.
• W2912588922 hasConceptScore W2912588922C2780871563 @default.
• W2912588922 hasConceptScore W2912588922C42219234 @default.
• W2912588922 hasConceptScore W2912588922C46721173 @default.
• W2912588922 hasConceptScore W2912588922C55493867 @default.
• W2912588922 hasConceptScore W2912588922C71924100 @default.
• W2912588922 hasConceptScore W2912588922C93248783 @default.

• next