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- W2912589658 abstract "Pim kinases have been targets of interest for a number of therapeutic areas. Evidence of durable single-agent efficacy in human clinical trials validated Pim kinase inhibition as a promising therapeutic approach for multiple myeloma patients. Here, we report the compound optimization leading to GDC-0339 (16), a potent, orally bioavailable, and well tolerated pan-Pim kinase inhibitor that proved efficacious in RPMI8226 and MM.1S human multiple myeloma xenograft mouse models and has been evaluated as an early development candidate." @default.
- W2912589658 created "2019-02-21" @default.
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- W2912589658 date "2019-02-04" @default.
- W2912589658 modified "2023-10-16" @default.
- W2912589658 title "Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma" @default.
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- W2912589658 doi "https://doi.org/10.1021/acs.jmedchem.8b01857" @default.
- W2912589658 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30715878" @default.
- W2912589658 hasPublicationYear "2019" @default.
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