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• W2912590058 abstract "A clinical isolate of measles virus (MeV) bearing a single amino acid alteration in the viral fusion protein (F; L454W) was previously identified in two patients with lethal sequelae of MeV central nervous system (CNS) infection. The mutation dysregulated the viral fusion machinery so that the mutated F protein mediated cell fusion in the absence of known MeV cellular receptors. While this virus could feasibly have arisen via intrahost evolution of the wild-type (wt) virus, it was recently shown that the same mutation emerged under the selective pressure of small-molecule antiviral treatment. Under these conditions, a potentially neuropathogenic variant emerged outside the CNS. While CNS adaptation of MeV was thought to generate viruses that are less fit for interhost spread, we show that two animal models can be readily infected with CNS-adapted MeV via the respiratory route. Despite bearing a fusion protein that is less stable at 37°C than the wt MeV F, this virus infects and replicates in cotton rat lung tissue more efficiently than the wt virus and is lethal in a suckling mouse model of MeV encephalitis even with a lower inoculum. Thus, either during lethal MeV CNS infection or during antiviral treatment in vitro, neuropathogenic MeV can emerge, can infect new hosts via the respiratory route, and is more pathogenic (at least in these animal models) than wt MeV.IMPORTANCE Measles virus (MeV) infection can be severe in immunocompromised individuals and lead to complications, including measles inclusion body encephalitis (MIBE). In some cases, MeV persistence and subacute sclerosing panencephalitis (SSPE) occur even in the face of an intact immune response. While they are relatively rare complications of MeV infection, MIBE and SSPE are lethal. This work addresses the hypothesis that despite a dysregulated viral fusion complex, central nervous system (CNS)-adapted measles virus can spread outside the CNS within an infected host." @default.
• W2912590058 created "2019-02-21" @default.
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• W2912590058 date "2019-04-15" @default.
• W2912590058 modified "2023-10-16" @default.
• W2912590058 title "Measles Virus Bearing Measles Inclusion Body Encephalitis-Derived Fusion Protein Is Pathogenic after Infection via the Respiratory Route" @default.
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• W2912590058 cites W1803102843 @default.
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• W2912590058 cites W1977926168 @default.
• W2912590058 cites W1990736754 @default.
• W2912590058 cites W1995877370 @default.
• W2912590058 cites W2006065181 @default.
• W2912590058 cites W2012735516 @default.
• W2912590058 cites W2013123687 @default.
• W2912590058 cites W2013602396 @default.
• W2912590058 cites W2019915962 @default.
• W2912590058 cites W2022534345 @default.
• W2912590058 cites W2036073704 @default.
• W2912590058 cites W2039635444 @default.
• W2912590058 cites W2047090987 @default.
• W2912590058 cites W2059869414 @default.
• W2912590058 cites W2065178191 @default.
• W2912590058 cites W2067270269 @default.
• W2912590058 cites W2067847775 @default.
• W2912590058 cites W2069450123 @default.
• W2912590058 cites W2076289267 @default.
• W2912590058 cites W2081569298 @default.
• W2912590058 cites W2082746416 @default.
• W2912590058 cites W2084594266 @default.
• W2912590058 cites W2086704075 @default.
• W2912590058 cites W2091782816 @default.
• W2912590058 cites W2096025413 @default.
• W2912590058 cites W2096621427 @default.
• W2912590058 cites W2099480075 @default.
• W2912590058 cites W2099695246 @default.
• W2912590058 cites W2099788034 @default.
• W2912590058 cites W2100255826 @default.
• W2912590058 cites W2105825428 @default.
• W2912590058 cites W2111625216 @default.
• W2912590058 cites W2111902258 @default.
• W2912590058 cites W2114168749 @default.
• W2912590058 cites W2120216339 @default.
• W2912590058 cites W2120434154 @default.
• W2912590058 cites W2132120238 @default.
• W2912590058 cites W2134354003 @default.
• W2912590058 cites W2135839939 @default.
• W2912590058 cites W2139219208 @default.
• W2912590058 cites W2144840869 @default.
• W2912590058 cites W2145816564 @default.
• W2912590058 cites W2154625168 @default.
• W2912590058 cites W2155442345 @default.
• W2912590058 cites W2156309934 @default.
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• W2912590058 cites W2167832495 @default.
• W2912590058 cites W2190008856 @default.
• W2912590058 cites W2285722815 @default.
• W2912590058 cites W2414767233 @default.
• W2912590058 cites W2514907620 @default.
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• W2912590058 doi "https://doi.org/10.1128/jvi.01862-18" @default.
• W2912590058 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6450100" @default.
• W2912590058 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30728259" @default.
• W2912590058 hasPublicationYear "2019" @default.
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