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- W2912590786 abstract "Bioelectricity remains at the forefront of scientific mystery. Persisting endogenous electric fields have proven an essential mediator for the development and regeneration of tissue. Chondrocytes, the native cartilage producing cells, exhibit increased collagen and aggrecan production along with directional migration in response to an electric field. Given the piezoelectric nature of cartilage with the ever-present mechanical strain fluctuations; it is likely that chondrocytes possess sensitive sensing/response mechanisms to coordinate with the fluctuating electric fields. Under an electric field spatial distribution of membrane potential can be induced. Curiously, chondrocytes possess a low plasma membrane potential more akin to cells with greater proliferation potential such as stem cells and cancer cells. Interestingly, in cancer cells, the ion channel Kir4.2 was described as a sensor to the electric field. An abundance of ion channels exists within chondrocytes; many of which are activated by mechanical pressure, changes in pH, and osmolarity. We hypothesized that chondrocyte ion channels may be modulated by electric fields. Because chondrocytes lose their differentiation properties when grown in 2D tissue culture compared to 3D, it is important to factor this into experimental set-ups. We fabricated a 3D printed device for the electrotactic study of cells in a 3D collagen matrix. COMSOL models were generated to qualitatively observe cells' spatial and temporal response to electrical cues. Gene expression changes were determined by qRT-PCR in cells exposed to an electric field and compared to sham controls. Given the wave of cartilage regeneration treatments being pioneered, chondrocytes are of particular interest to identify the mechanism by which electrotactic migration is induced. With knowledge of this mechanism treatments can be optimized for accelerated cartilage repair." @default.
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- W2912590786 date "2019-02-01" @default.
- W2912590786 modified "2023-09-27" @default.
- W2912590786 title "Navigational Bioelectricity: Search for the Elusive Sensor of Electric Fields in Chondrocytes" @default.
- W2912590786 doi "https://doi.org/10.1016/j.bpj.2018.11.2391" @default.
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