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- W2912591947 abstract "Background Graft-versus-host disease (GVHD) is a major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (HSCT). Previous studies have shown that anti- thymocyte globulin (ATG) reduce the incidence of acute and or chronic GVHD after reduced intensity and chemotherapy based myeloablative conditioning regimen pre-HSCT. The impact of the use of ATG following TBI based myeloablative conditioning regimen has been poorly explored. Recent prospective, double-blind phase III study of ATG vs placebo in patients (pts) with MDS or AML following myeloablative conditioning report inferior progression-free survival (PFS) and overall survival (OS) in the ATG arm, especially in the TBI cohort. However, this study includes only small and quite heterogeneous sub-populations within the TBI group. We therefore assessed the effect of ATG in a large homogenous cohort of AML pts undergoing HSCT with TBI and reported to the ALWP of the EBMT. Methods The study included 724 AML pts that underwent HSCT during the years 2008-2016 from a matched sibling (n=412) or 9-10 unrelated donor (n=312), following TBI (>8Gy) based conditioning regimen. All disease statuses were included (CR1=489, CR2=148; refractor=87). Graft source was PB in the majority of pts (n=579, 80%). 251 pts received ATG while 473 did not. Median follow up was 58.8 (28-83) months. The disease and transplant characteristics were similar in both groups except for type of donors, unrelated donor HSCT received ATG in 89% vs 19% in sibling donor HSCT (p Results In univariate analysis, day 100 incidence of acute GVHD II-IV and III-VI was 24.1% vs 33% (p Conclusions The addition of ATG to TBI based conditioning regimen followed by HSCT for AML results in significant reduction of acute and chronic GVHD, translating into a significant reduction in TRM without increasing relapse rate, and a similar LFS or OS." @default.
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- W2912591947 date "2019-03-01" @default.
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- W2912591947 title "Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia Following Total Body Irradiation- the Effect of Anti- Thymocyte Globulin on Transplant Outcome: ALWP of the EBMT Study" @default.
- W2912591947 doi "https://doi.org/10.1016/j.bbmt.2018.12.772" @default.
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