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- W2912592844 abstract "Introduction: Immune-mediated mechanisms are believed to play an important pathogenetic role in chronic hepatitis B virus infection. Interleukin IL-10 secreted by T helper-2 cells may down regulate cell-mediated immune effector mechanisms important in the host defence against intracellular pathogens. This study was designed to investigate the role of IL 10 polymorphism in HBV related liver diseases from India. Methods: A total of 178 hepatitis B related cases [chronic hepatitis B (50), decompensated cirrhosis 50), hepatocellular carcinoma (40), asymptomatic carriers (50)] and 100 healthy controls were included in the study. All cases were evaluated for viral markers by third generation ELISA. IL-10 polymorphism (at position -1082,-592 and -819) were analysed by polymerase chain reaction followed by RFLP. Results: In position -819 CC, TT and CT was observed, statistical significance was observed for genotype CC in decompensated cirrhosis cases (p= 0.003) and HCC cases (p=0.001) compared against the controls. An increased risk of almost 4 fold and 9 fold was observed in these two groups respectively. Genotype TT was found to be significant in cases of decompensated cirrhosis (p= 0.025) and HCC (p=0.01). Genotype CT was not found to be significant in either of the groups. On the other hand no significance was documented for AA and GA genotype at position -1082 and AA, CC and CA genotype at position -592 when compared with the healthy controls. Conclusion: The CC Allele at the IL-10 gene promoter (-819) is associated with 4 fold increase in risk of progression of the disease to cirrhosis and 9 fold increase in risk of progression of the disease to HCC." @default.
- W2912592844 created "2019-02-21" @default.
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- W2912592844 date "2017-10-01" @default.
- W2912592844 modified "2023-09-27" @default.
- W2912592844 title "Role of IL-10 Promoter Polymorphism in HBV-Related Liver Disease Patients" @default.
- W2912592844 doi "https://doi.org/10.14309/00000434-201710001-01030" @default.
- W2912592844 hasPublicationYear "2017" @default.
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