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- W2912593732 endingPage "388" @default.
- W2912593732 startingPage "371" @default.
- W2912593732 abstract "Despite significant effort, understanding the causes and mechanisms of human aging and longevity remains a fundamental challenge to researchers. In recent years, new discoveries have led to a rethinking of the classical evolutionary models of aging, shifting the emphasis from causative genetic factors to epigenetic and environmental effects. In light of existing discoveries, this chapter will describe the main developments in the field of aging epigenetics, with particular emphasis on the impact of DNA methylation changes in age-dependent phenotypes. Furthermore, the involvement and mechanisms of chromatin rearrangements during aging are discussed, including various histone modifications, sirtuins, noncoding RNAs, polycomb group genes and telomere-length homeostasis. Additionally, the utility of twin studies in estimating the relative importance of epigenetic components in the aging process will be covered. Finally, a revised model of epigenetic drift in aging will be presented, taking into account the classical evolutionary theories of aging." @default.
- W2912593732 created "2019-02-21" @default.
- W2912593732 creator A5000120239 @default.
- W2912593732 date "2017-01-01" @default.
- W2912593732 modified "2023-09-25" @default.
- W2912593732 title "Aging Epigenetics" @default.
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