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- W2912595443 abstract "本试验旨在研究脱氧雪腐镰刀菌烯醇（DON）与黄曲霉毒素B1（AFB1）单一及联合染毒对小鼠肠道菌群多样性、物种丰度的影响。选用18日龄昆明系雄性小鼠96只，随机分成4组，每组24只。其中，对照组灌服生理盐水，DON组灌服500 μg/kg DON，AFB1组灌服200 μg/kg AFB1，DON+AFB1组灌服200 μg/kg AFB1+500 μg/kg DON，连续灌服45 d。分别在试验第0天（试验开始前）、第45天时，无菌条件下采取直肠内新鲜粪便，每组随机采取3份，用Illumina HiSeq高通量测序技术分析肠道菌群结构和组成的变化。结果显示：与对照组相比，DON组、AFB1组以及DON+AFB1组拟杆菌门和拟杆菌纲的丰度均极显著低于对照组（P < 0.01）。与DON组和AFB1组相比，DON+AFB1组拟杆菌纲的丰度极显著降低（P < 0.01）。DON组、AFB1组以及DON+AFB1组脱铁杆菌门的丰度与对照组相比均极显著降低（P < 0.01）。DON组、AFB1组以及DON+AFB1组梭菌纲的丰度极显著高于对照组（P < 0.01）。DON组和DON+AFB1组螺旋体门的丰度与对照组相比极显著升高（P < 0.01）。综上所述，DON与AFB1单一及联合染毒均可改变肠道内菌群的丰度，降低有益菌丰度，升高有害菌丰度，并且DON和AFB1表现出明显的互作性，具有协同效应。" @default.
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- W2912595443 date "2019-02-25" @default.
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- W2912595443 title "脱氧雪腐镰刀菌烯醇与黄曲霉毒素B 1 单一及联合染毒对小鼠肠道菌群的影响" @default.
- W2912595443 doi "https://doi.org/10.3969/j.issn.1006-267x.2019.02.047" @default.
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