Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912595852> ?p ?o ?g. }
- W2912595852 endingPage "745" @default.
- W2912595852 startingPage "738" @default.
- W2912595852 abstract "Abstract Peptide display approaches, in which peptide epitopes of known binding activities are grafted onto stable protein scaffolds, have been developed to constrain the peptide in its bioactive conformation and to enhance its stability. However, peptide grafting can be a lengthy process requiring extensive computational modeling and/or optimisation by directed evolution techniques. In this study, we show that ultra‐stable consensus‐designed tetratricopeptide repeat (CTPR) proteins are amenable to the grafting of peptides that bind the Kelch‐like ECH‐associated protein 1 (Keap1) onto the loop between adjacent repeats. We explore simple strategies to optimize the grafting process and show that modest improvements in Keap1‐binding affinity can be obtained by changing the composition of the linker sequence flanking either side of the binding peptide." @default.
- W2912595852 created "2019-02-21" @default.
- W2912595852 creator A5043085718 @default.
- W2912595852 creator A5052850050 @default.
- W2912595852 creator A5054468698 @default.
- W2912595852 date "2019-03-19" @default.
- W2912595852 modified "2023-09-26" @default.
- W2912595852 title "Exploring new strategies for grafting binding peptides onto protein loops using a consensus‐designed tetratricopeptide repeat scaffold" @default.
- W2912595852 cites W1764690254 @default.
- W2912595852 cites W1807130047 @default.
- W2912595852 cites W1846364398 @default.
- W2912595852 cites W1849202109 @default.
- W2912595852 cites W1884499457 @default.
- W2912595852 cites W1912933662 @default.
- W2912595852 cites W197322975 @default.
- W2912595852 cites W1974546855 @default.
- W2912595852 cites W2001365065 @default.
- W2912595852 cites W2009659607 @default.
- W2912595852 cites W2009828575 @default.
- W2912595852 cites W2018687970 @default.
- W2912595852 cites W2021374358 @default.
- W2912595852 cites W2033447440 @default.
- W2912595852 cites W2036053067 @default.
- W2912595852 cites W2039168932 @default.
- W2912595852 cites W2043094531 @default.
- W2912595852 cites W2043988505 @default.
- W2912595852 cites W2049631853 @default.
- W2912595852 cites W2055490020 @default.
- W2912595852 cites W2056924642 @default.
- W2912595852 cites W2069871720 @default.
- W2912595852 cites W2070395999 @default.
- W2912595852 cites W2080748572 @default.
- W2912595852 cites W2085265183 @default.
- W2912595852 cites W2093067321 @default.
- W2912595852 cites W2094661084 @default.
- W2912595852 cites W2095447949 @default.
- W2912595852 cites W2109339916 @default.
- W2912595852 cites W2110882545 @default.
- W2912595852 cites W2115746274 @default.
- W2912595852 cites W2127368222 @default.
- W2912595852 cites W2141982524 @default.
- W2912595852 cites W2143558515 @default.
- W2912595852 cites W2152044968 @default.
- W2912595852 cites W2153825083 @default.
- W2912595852 cites W2171218310 @default.
- W2912595852 cites W2319822095 @default.
- W2912595852 cites W2401030213 @default.
- W2912595852 cites W2568226856 @default.
- W2912595852 cites W2571630768 @default.
- W2912595852 cites W2582870217 @default.
- W2912595852 cites W2608076068 @default.
- W2912595852 cites W2736283795 @default.
- W2912595852 cites W2747985915 @default.
- W2912595852 cites W2766230432 @default.
- W2912595852 cites W2807208608 @default.
- W2912595852 cites W4301964598 @default.
- W2912595852 cites W598738849 @default.
- W2912595852 doi "https://doi.org/10.1002/pro.3586" @default.
- W2912595852 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6423998" @default.
- W2912595852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30746804" @default.
- W2912595852 hasPublicationYear "2019" @default.
- W2912595852 type Work @default.
- W2912595852 sameAs 2912595852 @default.
- W2912595852 citedByCount "8" @default.
- W2912595852 countsByYear W29125958522020 @default.
- W2912595852 countsByYear W29125958522021 @default.
- W2912595852 countsByYear W29125958522022 @default.
- W2912595852 crossrefType "journal-article" @default.
- W2912595852 hasAuthorship W2912595852A5043085718 @default.
- W2912595852 hasAuthorship W2912595852A5052850050 @default.
- W2912595852 hasAuthorship W2912595852A5054468698 @default.
- W2912595852 hasBestOaLocation W29125958521 @default.
- W2912595852 hasConcept C104317684 @default.
- W2912595852 hasConcept C111919701 @default.
- W2912595852 hasConcept C178790620 @default.
- W2912595852 hasConcept C185592680 @default.
- W2912595852 hasConcept C188018408 @default.
- W2912595852 hasConcept C21951064 @default.
- W2912595852 hasConcept C2775937945 @default.
- W2912595852 hasConcept C2778112365 @default.
- W2912595852 hasConcept C2779281246 @default.
- W2912595852 hasConcept C2780557392 @default.
- W2912595852 hasConcept C41008148 @default.
- W2912595852 hasConcept C521977710 @default.
- W2912595852 hasConcept C55493867 @default.
- W2912595852 hasConcept C70721500 @default.
- W2912595852 hasConcept C71829478 @default.
- W2912595852 hasConcept C77088390 @default.
- W2912595852 hasConcept C86803240 @default.
- W2912595852 hasConcept C89429830 @default.
- W2912595852 hasConceptScore W2912595852C104317684 @default.
- W2912595852 hasConceptScore W2912595852C111919701 @default.
- W2912595852 hasConceptScore W2912595852C178790620 @default.
- W2912595852 hasConceptScore W2912595852C185592680 @default.
- W2912595852 hasConceptScore W2912595852C188018408 @default.
- W2912595852 hasConceptScore W2912595852C21951064 @default.
- W2912595852 hasConceptScore W2912595852C2775937945 @default.
- W2912595852 hasConceptScore W2912595852C2778112365 @default.