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• W2912596499 endingPage "737.e3" @default.
• W2912596499 startingPage "727" @default.
• W2912596499 abstract "CRISPR-Cas immunity requires integration of short, foreign DNA fragments into the host genome at the CRISPR locus, a site consisting of alternating repeat sequences and foreign-derived spacers. In most CRISPR systems, the proteins Cas1 and Cas2 form the integration complex and are both essential for DNA acquisition. Most type V-C and V-D systems lack the cas2 gene and have unusually short CRISPR repeats and spacers. Here, we show that a mini-integrase comprising the type V-C Cas1 protein alone catalyzes DNA integration with a preference for short (17- to 19-base-pair) DNA fragments. The mini-integrase has weak specificity for the CRISPR array. We present evidence that the Cas1 proteins form a tetramer for integration. Our findings support a model of a minimal integrase with an internal ruler mechanism that favors shorter repeats and spacers. This minimal integrase may represent the function of the ancestral Cas1 prior to Cas2 adoption." @default.
• W2912596499 created "2019-02-21" @default.
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• W2912596499 date "2019-02-01" @default.
• W2912596499 modified "2023-10-16" @default.
• W2912596499 title "A Functional Mini-Integrase in a Two-Protein Type V-C CRISPR System" @default.
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• W2912596499 doi "https://doi.org/10.1016/j.molcel.2018.12.015" @default.
• W2912596499 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6386590" @default.
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• W2912596499 hasPublicationYear "2019" @default.
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