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- W2912597034 abstract "We appreciate the interest in our article, “Yttrium-90 Radioembolization of Advanced, Unresectable Breast Cancer Liver Metastases—a Single-Center Experience” ( 1 Pieper C.C. Meyer C. Wilhelm K.E. et al. Yttrium-90 radioembolization of advanced, unresectable breast cancer liver metastases—a single-center experience. J Vasc Interv Radiol. 2016; 27: 1305-1315 Abstract Full Text Full Text PDF PubMed Scopus (37) Google Scholar ). Dr. Altundag draws attention to the importance of endocrine therapy in hormone receptor–positive metastatic breast cancer, which is also reflected in international guidelines ( 2 Cardoso F. Costa A. Norton L. et al. ESO-ESMO 2nd international consensus guidelines for advanced breast cancer (ABC2). Breast. 2014; 23: 489-502 Abstract Full Text Full Text PDF PubMed Scopus (252) Google Scholar ). We agree with Dr. Altundag that sequential endocrine treatment is an important part of standard initial therapy in such cases. However, as also recognized by the aforementioned guidelines, primary or secondary endocrine resistance may occur with subsequent disease relapse. Several mechanisms (eg, receptor mutation) can lead to acquired resistance to endocrine treatment ( 3 Merenbakh-Lamin K. Ben-Baruch N. Yeheskel A. et al. D538G mutation in estrogen receptor-α: a novel mechanism for acquired endocrine resistance in breast cancer. Cancer Res. 2013; 73: 6856-6864 Crossref PubMed Scopus (291) Google Scholar ), and thus the primary tumor and metastases may respond differently. It is important to recognize that the patient cohort reported in our article comprises patients with advanced metastatic breast cancer with therapy-refractory hepatic metastases. Endocrine Treatment Is Still the Main Option in the Management of Metastatic Breast Cancer Patients with Liver-Dominant MetastasesJournal of Vascular and Interventional RadiologyVol. 27Issue 12PreviewI read with great interest the article by Pieper et al (1) addressing yttrium-90 radioembolization of liver metastases in patients with metastatic breast cancer patients. The authors conclude that transarterial radioembolization can successfully delay progression of therapy-refractory liver-dominant breast metastases with low complication rate. Almost 60% of their patient population had hormone receptor–positive disease. However, the authors did not give detailed information about history of endocrine treatment in these patients. Full-Text PDF" @default.
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- W2912597034 date "2016-12-01" @default.
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- W2912597034 title "Letter To The Editor" @default.
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- W2912597034 doi "https://doi.org/10.1016/j.jvir.2016.09.013" @default.
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