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• W2912598275 abstract "We read with interest the letter by Jones et al regarding our retrospective study of a cohort of patients undergoing trabeculectomy with mitomycin C. They raised three issues:1We do not customarily supplement intraoperative mitomycin C with postoperative subconjunctival 5-fluorouracil injections. Therefore, this group was a pure group of patients who underwent trabeculectomy with intraoperative mitomycin C only. We do not customarily add postoperative 5-fluorouracil injections because (1) we are concerned about the excess bleb morbidity that may be caused by supplemental 5-fluorouracil injections, and (2) we are unaware of any controlled study that shows that 5-fluorouracil added to intraoperative mitomycin C is effective.2The fact that our results do not agree with those of the Advanced Glaucoma Interventional Study certainly does not invalidate the results in this different group of patients. It is in incorrect to conclude that because “only” 13% of patients had prior laser trabeculoplasty, a positive association is dubious. If the results had been negative, a lack of power would be an issue. Because the results are positive, it is a robust and statistically valid finding. It is always possible, of course, that the association can occur by chance alone with a P value of 0.05. In fact, by definition there is a 5% chance of this happening: this is basic statistics.3The remark regarding adjustments for potential confounding factors indicates an inattention to the statistical methods described in the article. We clearly stated that all the potential variables that we could identify as possibly confounding were included in the model to adjust for these effects properly.We hope these remarks clarify the questions raised by Jones et al. We read with interest the letter by Jones et al regarding our retrospective study of a cohort of patients undergoing trabeculectomy with mitomycin C. They raised three issues:1We do not customarily supplement intraoperative mitomycin C with postoperative subconjunctival 5-fluorouracil injections. Therefore, this group was a pure group of patients who underwent trabeculectomy with intraoperative mitomycin C only. We do not customarily add postoperative 5-fluorouracil injections because (1) we are concerned about the excess bleb morbidity that may be caused by supplemental 5-fluorouracil injections, and (2) we are unaware of any controlled study that shows that 5-fluorouracil added to intraoperative mitomycin C is effective.2The fact that our results do not agree with those of the Advanced Glaucoma Interventional Study certainly does not invalidate the results in this different group of patients. It is in incorrect to conclude that because “only” 13% of patients had prior laser trabeculoplasty, a positive association is dubious. If the results had been negative, a lack of power would be an issue. Because the results are positive, it is a robust and statistically valid finding. It is always possible, of course, that the association can occur by chance alone with a P value of 0.05. In fact, by definition there is a 5% chance of this happening: this is basic statistics.3The remark regarding adjustments for potential confounding factors indicates an inattention to the statistical methods described in the article. We clearly stated that all the potential variables that we could identify as possibly confounding were included in the model to adjust for these effects properly. We hope these remarks clarify the questions raised by Jones et al. Trabeculectomy with Mitomycin COphthalmologyVol. 114Issue 6PreviewFontana et al presented the 3-year outcomes of a retrospective cohort of low-risk primary trabeculectomy augmented with mitomycin C.1 We commend them for the design and their use of the stratified outcomes criteria for the evaluation and presentation of their results. Full-Text PDF" @default.
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• W2912598275 date "2007-06-01" @default.
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• W2912598275 doi "https://doi.org/10.1016/j.ophtha.2007.03.028" @default.
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