Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912600407> ?p ?o ?g. }
- W2912600407 abstract "Abstract The microbiome is generally assumed to have a substantial influence on the biology of multicellular organisms. The exact functional contributions of the microbes are often unclear and cannot be inferred easily from 16S rRNA genotyping, which is commonly used for taxonomic characterization of the bacterial associates. In order to bridge this knowledge gap, we here analyzed the metabolic competences of the native microbiome of the model nematode Caenorhabditis elegans . We integrated whole genome sequences of 77 bacterial microbiome members with metabolic modelling and experimental characterization of bacterial physiology. We found that, as a community, the microbiome can synthesize all essential nutrients for C. elegans . Both metabolic models and experimental analyses further revealed that nutrient context can influence how bacteria interact within the microbiome. We identified key bacterial traits that are likely to influence the microbe’s ability to colonize C. elegans (e.g., pyruvate fermentation to acetoin) and the resulting effects on nematode fitness (e.g., hydroxyproline degradation). Considering that the microbiome is usually neglected in the comprehensive research on this nematode, the resource presented here will help our understanding of C. elegans biology in a more natural context. Our integrative approach moreover provides a novel, general framework to dissect microbiome-mediated functions." @default.
- W2912600407 created "2019-02-21" @default.
- W2912600407 creator A5005182135 @default.
- W2912600407 creator A5020027850 @default.
- W2912600407 creator A5022049273 @default.
- W2912600407 creator A5035843144 @default.
- W2912600407 creator A5036040974 @default.
- W2912600407 creator A5036098112 @default.
- W2912600407 creator A5042312950 @default.
- W2912600407 creator A5044643040 @default.
- W2912600407 creator A5046169109 @default.
- W2912600407 creator A5046519659 @default.
- W2912600407 creator A5052040351 @default.
- W2912600407 creator A5053118854 @default.
- W2912600407 creator A5064413068 @default.
- W2912600407 creator A5066331469 @default.
- W2912600407 creator A5069939758 @default.
- W2912600407 date "2019-02-19" @default.
- W2912600407 modified "2023-09-26" @default.
- W2912600407 title "The functional repertoire encoded within the native microbiome of the model nematode Caenorhabditis elegans" @default.
- W2912600407 cites W1135054281 @default.
- W2912600407 cites W1964306176 @default.
- W2912600407 cites W1974162074 @default.
- W2912600407 cites W1977556410 @default.
- W2912600407 cites W1992102609 @default.
- W2912600407 cites W1993519767 @default.
- W2912600407 cites W1993839684 @default.
- W2912600407 cites W2009906860 @default.
- W2912600407 cites W2023442759 @default.
- W2912600407 cites W2034285706 @default.
- W2912600407 cites W2043302270 @default.
- W2912600407 cites W2044935306 @default.
- W2912600407 cites W2045843097 @default.
- W2912600407 cites W2049341230 @default.
- W2912600407 cites W2054679205 @default.
- W2912600407 cites W2055424972 @default.
- W2912600407 cites W2091030812 @default.
- W2912600407 cites W2094201044 @default.
- W2912600407 cites W2096093282 @default.
- W2912600407 cites W2096339276 @default.
- W2912600407 cites W2100084634 @default.
- W2912600407 cites W2100365580 @default.
- W2912600407 cites W2103441770 @default.
- W2912600407 cites W2117681000 @default.
- W2912600407 cites W2120902911 @default.
- W2912600407 cites W2121514092 @default.
- W2912600407 cites W2126452774 @default.
- W2912600407 cites W2128769815 @default.
- W2912600407 cites W2131271579 @default.
- W2912600407 cites W2133707124 @default.
- W2912600407 cites W2137020823 @default.
- W2912600407 cites W2148211715 @default.
- W2912600407 cites W2152839556 @default.
- W2912600407 cites W2155943701 @default.
- W2912600407 cites W2161478038 @default.
- W2912600407 cites W2162314899 @default.
- W2912600407 cites W2173913502 @default.
- W2912600407 cites W2175743436 @default.
- W2912600407 cites W2185547054 @default.
- W2912600407 cites W2191348358 @default.
- W2912600407 cites W2234623689 @default.
- W2912600407 cites W2265714433 @default.
- W2912600407 cites W2317201147 @default.
- W2912600407 cites W2345465785 @default.
- W2912600407 cites W2346617299 @default.
- W2912600407 cites W2433871124 @default.
- W2912600407 cites W2465388906 @default.
- W2912600407 cites W2472391846 @default.
- W2912600407 cites W2517374056 @default.
- W2912600407 cites W2520355709 @default.
- W2912600407 cites W2557117995 @default.
- W2912600407 cites W2559597060 @default.
- W2912600407 cites W2597578033 @default.
- W2912600407 cites W2599156762 @default.
- W2912600407 cites W2605068739 @default.
- W2912600407 cites W2605441431 @default.
- W2912600407 cites W2606663123 @default.
- W2912600407 cites W2617261748 @default.
- W2912600407 cites W2625708948 @default.
- W2912600407 cites W2732407785 @default.
- W2912600407 cites W2739340114 @default.
- W2912600407 cites W2741961591 @default.
- W2912600407 cites W2748607273 @default.
- W2912600407 cites W2767088268 @default.
- W2912600407 cites W2767593460 @default.
- W2912600407 cites W2803987722 @default.
- W2912600407 cites W4236499502 @default.
- W2912600407 cites W4243859336 @default.
- W2912600407 doi "https://doi.org/10.1101/554345" @default.
- W2912600407 hasPublicationYear "2019" @default.
- W2912600407 type Work @default.
- W2912600407 sameAs 2912600407 @default.
- W2912600407 citedByCount "0" @default.
- W2912600407 crossrefType "posted-content" @default.
- W2912600407 hasAuthorship W2912600407A5005182135 @default.
- W2912600407 hasAuthorship W2912600407A5020027850 @default.
- W2912600407 hasAuthorship W2912600407A5022049273 @default.
- W2912600407 hasAuthorship W2912600407A5035843144 @default.
- W2912600407 hasAuthorship W2912600407A5036040974 @default.
- W2912600407 hasAuthorship W2912600407A5036098112 @default.