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- W2912603065 abstract "The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are ligand-activated nuclear receptors (NRs) that are notorious for their role in drug metabolism, causing unintended drug-drug interactions and decreasing drug efficacy. They control the xenobiotic detoxification system by regulating the expression of an array of drug-metabolizing enzymes and transporters that excrete exogenous chemicals and maintain homeostasis of endogenous metabolites. Much effort has been invested in recognizing potential drugs for clinical use that can activate PXR and CAR to enhance the expression of their target genes, and in identifying PXR and CAR inhibitors that can be used as co-therapeutics to prevent adverse effects. Here, we present current technologies and assays used in the quest to characterize PXR and CAR modulators, which range from biochemical to cell-based and animal models." @default.
- W2912603065 created "2019-02-21" @default.
- W2912603065 creator A5053474198 @default.
- W2912603065 creator A5055247164 @default.
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- W2912603065 creator A5075326108 @default.
- W2912603065 date "2019-03-01" @default.
- W2912603065 modified "2023-10-18" @default.
- W2912603065 title "Drug discovery technologies to identify and characterize modulators of the pregnane X receptor and the constitutive androstane receptor" @default.
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- W2912603065 doi "https://doi.org/10.1016/j.drudis.2019.01.021" @default.
- W2912603065 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6421094" @default.
- W2912603065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30731240" @default.
- W2912603065 hasPublicationYear "2019" @default.
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