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- W2912603626 abstract "Abstract Memory-guided decisions depend on complex, finely tuned interactions between hippocampus and medial mesocortical regions anterior cingulate and retrosplenial cortices. The functional circuitry underlying these interactions is unclear. Using viral anatomical tracing, in vitro and in vivo electrophysiology, and optogenetics, we show that such circuitry is characterized by a functional-anatomical gradient. While CG receives excitatory projections from dorsal-intermediate CA1 originated exclusively in stratum pyramidale , retrosplenial cortex also receives inputs originating in stratum radiatum and lacunosum-moleculare , including GAD+ neurons providing long-range GABAergic projections. Such hippocampal projections establish bona fide synapses throughout cortical layers, with retrosplenial cortex densely targeted on its layer 3, around which it receives a combination of inhibitory and excitatory synapses. This gradient is reflected in the pattern of spontaneous oscillatory synchronicity found in the awake-behaving animal, compatible with the known functional similarity of hippocampus with retrosplenial cortex, which contrasts with the encoding of actions and “task-space” by cingulate cortex. Highlights Both MMC regions CG and RSC receive monosynaptic connections from the dorsal-intermediate CA1 CG receives layer-sparse excitatory projections exclusively originated from stratum piramidale whereas RSC is targeted densely in superficial layers by a mixed excitatory and inhibitory input originating from all CA1 strata CA1 monosynaptic projections correspond to active synapses onto distinct layers of the two MMC regions Diverse synchrony between MMC and HIPP recorded in vivo is consistent with the rostro-caudal diversity of direct HIPP-MMC connections" @default.
- W2912603626 created "2019-02-21" @default.
- W2912603626 creator A5063429619 @default.
- W2912603626 creator A5082506391 @default.
- W2912603626 creator A5082757854 @default.
- W2912603626 date "2019-01-30" @default.
- W2912603626 modified "2023-09-25" @default.
- W2912603626 title "A Gradient of Hippocampal Inputs to the Medial Mesocortex" @default.
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- W2912603626 doi "https://doi.org/10.1101/535047" @default.
- W2912603626 hasPublicationYear "2019" @default.
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