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- W2912606752 abstract "The circulation of red blood cells (RBCs) in microchannels is important in microvascular blood flow and biomedical applications such as blood analysis in microfluidics. Current understanding of the complexity of RBC shapes and dynamical changes in microchannels is mainly formed by a number of simulation studies, but there are few systematic experimental investigations. Here, we present a first systematical mapping of experimental RBC shapes and dynamics for a wide range of flow rates and channel sizes. Results are compared with simulations and show good agreement. A key difference to simulations is that in experiments there is no single well-defined RBC state for fixed flow conditions, but rather a distribution of states. This result can be attributed to the inherent variability in RBC mechanical properties, which is confirmed by a model that takes the variation in RBC shear elasticity into account. These results make a significant step toward a quantitative connection between cell behavior in microfluidic devices and their mechanical properties." @default.
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- W2912606752 date "2019-02-01" @default.
- W2912606752 modified "2023-10-17" @default.
- W2912606752 title "High Troughput Microfluidic Characterization of Erythrocyte Shapes and Mechanical Variability" @default.
- W2912606752 doi "https://doi.org/10.1016/j.bpj.2018.11.688" @default.
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